Signal transducer and activator of transcription 5b

STAT5B
Identifiers
Aliases	STAT5B, STAT5, signal transducer and activator of transcription 5B
External IDs	MGI: 103035 HomoloGene: 55718 GeneCards: STAT5B
Gene location (Human) Chr. Chromosome 17 (human) Band 17q21.2 Start 42,199,168 bp End 42,276,707 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11 D|11 63.63 cM Start 100,780,731 bp End 100,850,724 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • signal transducer activity • glucocorticoid receptor binding • protein dimerization activity • chromatin binding • transcription factor activity, sequence-specific DNA binding • DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • protein binding • protein tyrosine kinase activity • RNA polymerase II core promoter proximal region sequence-specific DNA binding • RNA polymerase II transcription factor activity, sequence-specific DNA binding Cellular component • nucleoplasm • cytoplasm • cell nucleus • cytosol Biological process • positive regulation of natural killer cell differentiation • positive regulation of natural killer cell mediated cytotoxicity • regulation of steroid metabolic process • creatinine metabolic process • T cell differentiation in thymus • female pregnancy • cellular response to hormone stimulus • positive regulation of activated T cell proliferation • progesterone metabolic process • JAK-STAT cascade • negative regulation of apoptotic process • positive regulation of interleukin-2 biosynthetic process • Peyer's patch development • transcription, DNA-templated • signal transduction • cellular response to growth factor stimulus • natural killer cell differentiation • response to interleukin-4 • sex differentiation • valine metabolic process • positive regulation of B cell differentiation • T cell homeostasis • creatine metabolic process • cellular response to epidermal growth factor stimulus • response to estradiol • positive regulation of inflammatory response • regulation of transcription from RNA polymerase II promoter • mast cell migration • positive regulation of mitotic cell cycle • lipid storage • development of secondary female sexual characteristics • fatty acid metabolic process • taurine metabolic process • succinate metabolic process • positive regulation of gamma-delta T cell differentiation • positive regulation of lymphocyte differentiation • regulation of multicellular organism growth • citrate metabolic process • positive regulation of cell proliferation • oxaloacetate metabolic process • regulation of epithelial cell differentiation • positive regulation of natural killer cell proliferation • development of secondary male sexual characteristics • positive regulation of multicellular organism growth • regulation of transcription, DNA-templated • allantoin metabolic process • positive regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • luteinization • isoleucine metabolic process • negative regulation of erythrocyte differentiation • lactation • response to interleukin-15 • regulation of cell adhesion • 2-oxoglutarate metabolic process • response to interleukin-2 • JAK-STAT cascade involved in growth hormone signaling pathway • positive regulation of erythrocyte differentiation • peptidyl-tyrosine phosphorylation • interleukin-7-mediated signaling pathway • interleukin-15-mediated signaling pathway • cytokine-mediated signaling pathway • interleukin-2-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6777	20851
Ensembl	ENSG00000173757	ENSMUSG00000020919
UniProt	P51692	P42232
RefSeq (mRNA)	NM_012448	NM_001113563 NM_011489 NM_001362682
RefSeq (protein)	NP_036580	NP_001107035 NP_035619
Location (UCSC)	Chr 17: 42.2 – 42.28 Mb	Chr 11: 100.78 – 100.85 Mb
PubMed search

6777

20851

ENSG00000173757

ENSMUSG00000020919

P51692

P42232

NM_012448

NM_001113563
NM_011489
NM_001362682

NP_036580

NP_001107035
NP_035619

Signal transducer and activator of transcription 5B is a protein that in humans is encoded by the STAT5B gene.STAT5B orthologs have been identified in most placentals for which complete genome data are available.

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APML). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APML.

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