"Sick and Tired" is a song by American recording artist Anastacia from her third studio album, Anastacia. Written by Anastacia, Dallas Austin, and Glen Ballard, it was released as the album's second single on July 19, 2004 in Europe to positive reception from music critics. The single charted inside the top five in most of countries, including Austria, Denmark, Germany, Italy, the Netherlands, Spain, Switzerland, and the United Kingdom. "Sick and Tired" samples the song "Let The Music Play" by Shamur.

AllMusic editor Matthew Chisling said that Anastacia "seams a bit of R&B into her melodies." Caroline Sullivan of The Guardian wrote that on "Sick and Tired" Anastacia claims: "I'm sick and tired of being sick and tired. She sounds it." Andy Gill of The Independent clarified that this song is not ironically connected to Anastacia's fight with cancer but a "complaint about a lover's 'so malign' attitude."Stylus Magazine editor Dom Passantino referenced the sampled vocal in the song, opining "she can't just throw down some random Indian guy singing as a hook and then go 'Yo, whatever he said then I'm that'... except she does." He concluded that the song is "genuinely interesting, genuinely experimental, and [a] genuinely good single".

The music video for "Sick and Tired", directed by Philipp Stölzl, was shot in Los Angeles on May 25, 2004.

When the video begins, Anastacia is shown applying for a role and introduces herself as Sara Forest. Then she plays Holly in the film she is auditioning for. Throughout the video, Anastacia is performing the song in a small room with the band. The video is intercut with black-and-white scenes from the rehearsal on which their relationship is based. At first they fall in love, but after several dates, the boyfriend hits her, they split up and she wants him to leave.

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