Shishido Domain (常陸宍戸藩 Hitachi-Shishido-han) was a feudal domain under the Tokugawa shogunate of Edo period Japan, located in Hitachi Province (modern-day Ibaraki Prefecture), Japan. It was centered on Shishido Jin'ya in what is now part of the city of Kasama, Ibaraki. It was ruled for much of its history by a junior branch of the Mito Tokugawa clan.
When the new Tokugawa shogunate moved the powerful Satake clan north into Dewa Province, part of the lands they were given were occupied by the Akita clan. Shishido Domain was created for Akita Sanesue in 1602 out of part of the former Satake lands in Hitachi Province. He was replaced by his son Akita Toshisue in 1630, who was subsequently transferred to Miharu Domain in Mutsu Province and the domain reverted to direct control by the shogunate.
Shishido Domain was revived in 1682 for Matsudaira Yorio, the 7th son of Tokugawa Yorifusa of Mito Domain by order of Tokugawa Mitsukuni. The domain played a leading role in the pro-sonno joi Tengu Party Revolt of the early Bakumatsu period under the rule of Matsudaira Yorinori in 1864. After the failure of the revolt, Yorinori and many of the samurai of the domain were put to death and the domain officially suppressed. However, after the Meiji restoration, Shishido Domain was restored under Matsudaira Yoritaka, who was recalled from retirement and who served until the abolition of the han system in 1871.