Sheshequin Path

The Sheshequin Path was a major Native American trail in the U.S. State of Pennsylvania that ran between two Native American villages: "French Margaret's Town" on the West Branch Susquehanna River (part of modern-day Williamsport in Lycoming County) and "Sheshequin" on the North Branch of the Susquehanna River (modern-day Ulster Township, in Bradford County). The path ran north and east along Lycoming Creek in Lycoming County and followed much of Towanda Creek in Bradford County. It was a shortcut between the two main branches of the Susquehanna River and was used by early settlers as well as Native Americans.

The name Sheshequin is a corruption of Sheshequanink meaning "at the place of the gourd rattle" in the Lenape language. The gourd rattle was used in religious ceremonies held there. Another name for the trail was the "Lycoming Path" for the creek it runs along for much of its length, which also gave its name to Lycoming County. Lycoming is a corruption of the Lenape Legaui-hanne or "sandy stream". A shortcut near Sheshequin which bypassed Towanda was known as "St. Joseph's Path", believed to be named for the Moravian Bishop August Gottlieb Spangenberg, who was also known as "Brother Joseph".

As was often the case with Native American trails, the Sheshequin Path split into multiple pathways at each end. In Lycoming County there were three branches that eventually led to Lycoming Creek. Each connected with the Great Shamokin Path that ran along the West Branch Susquehanna River south to the village of Shamokin (modern Sunbury) and west to the "Great Island" (at modern Lock Haven) and further west to Kittanning on the Allegheny River.

...
Wikipedia