The Sheshatshiu Innu First Nation is located in the province of Newfoundland and Labrador, Canada. This First Nations band government is centred on the community of Sheshatshiu.
The current chief of the Sheshatshiu Innu First Nation is Engene Hart, who succeeded Andrew Penashue in 2015. The First Nation has a registered population of 1,447 people as of March 2013.