"She's Out of Her Mind" is a song recorded by American rock band Blink-182 for the group's seventh studio album, California (2016). The song was released as the second single from California on October 11, 2016 through BMG. Written by bassist Mark Hoppus, drummer Travis Barker, guitarist Matt Skiba, and producer John Feldmann, the song was re-written multiple times to make its chorus as catchy as possible. It contains lyrical references to the bands the Cure and Bauhaus. It was inspired by relationships the group had growing up with "crazy" girls.

The song peaked at number two Billboard's Alternative Songs chart. Critical reviews were mixed; some appreciated its "throwback" nature, while others considered it unoriginal. Its music video stars social media personalities running the streets of Los Angeles in the nude—a remake of the video for the band's 1999 song "What's My Age Again?". To promote the song, the group performed it on Jimmy Kimmel Live!.

Producer John Feldmann first came up with the lyrical concept for the song while walking around Disneyland with his children. He created the song's early working title, "Orange County Girl"—as Hoppus's wife, Skye Everly, is from Orange County, California, and Blink are a Southern California-based group. The song came together early in the recording process. According to producer John Feldmann, "We wanted to write a classic, no-brainer pop-punk song: major key, fun, happy, classic." The chorus was the result of multiple rewrites, with each draft attempting to perfect the chorus preceding it. "The end result is the combination of maybe four or five different choruses," Hoppus said. He considered it the song that was worked on the hardest while creating the album California, and a "deceptively simple song." As for its content, it was inspired by girls the band members dated while growing up that Hoppus summarized as "awesome, and a little bit crazy and a little bit dark."

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