"Shake That" (also known as "Shake That Ass") is the second and final single taken from American rapper Eminem's first compilation album, Curtain Call: The Hits (2005), following "When I'm Gone." It is one of three new songs featured on the album.

The song features Nate Dogg in a prominent vocal role, marking his sixth and final Eminem collaboration, following "Bitch Please II" from The Marshall Mathers LP, "Till I Collapse" from The Eminem Show, and "Never Enough" from Encore, and the two collaborated on Xzibit's "My Name", from the album Man vs. Machine and Lloyd Banks' "Warrior Part 2" on the album The Hunger for More. "Shake That" is the first of these songs to include Nate Dogg during verse, whereas his contributions in the other works are limited to the refrain and the outro. Contrary to many of the second singles from each of Eminem's albums, such as "The Way I Am", "Cleanin' Out My Closet", and "Like Toy Soldiers", which are usually much darker and more stern than their predecessors, "Shake That" is a departure from the serious tone of "When I'm Gone," representing a far more playful atmosphere. It focuses on Eminem and Nate Dogg rapping about seducing women into sex in cars, and strip clubs. The music video is animated, and follows this context from the song. The single was released in early 2006 in the United States. It became a big hit, peaking at #6. In the UK, the song was released as a download only single in April 2006, managing to peak at #28 on the UK Download Chart.

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