Settsu Province (摂津国 Settsu no kuni?) was a province of Japan, which today comprises the southeastern part of Hyōgo Prefecture and the northern part of Osaka Prefecture. It was also referred to as Tsu Province (津国 Tsu no kuni?) or Sesshū (摂州?).
Osaka and Osaka Castle were the main center of the province. Most of Settsu's area comprises the modern day cities of Osaka and Kōbe.
During the Sengoku period, the Miyoshi clan ruled Settsu and its neighbors, Izumi and Kawachi, until they were conquered by Oda Nobunaga. The provinces were ruled subsequently by Toyotomi Hideyoshi. The regents of Hideyoshi's son soon quarreled, and when Ishida Mitsunari lost the Battle of Sekigahara, the area was given to relatives of Tokugawa Ieyasu. It was from then on divided into several domains, including the Asada Domain.