Sepiapterin reductase

SPR
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1Z6Z, 4HWK, 4J7U, 4J7X, 4XWY, 4Z3K
Identifiers
Aliases	SPR, SDR38C1, sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
External IDs	MGI: 103078 HomoloGene: 37735 GeneCards: SPR
Gene ontology Molecular function • sepiapterin reductase activity • aldo-keto reductase (NADP) activity • NADP binding • oxidoreductase activity Cellular component • nucleoplasm • extracellular exosome • cytoplasm • cytosol Biological process • nitric oxide biosynthetic process • regulation of nitric-oxide synthase activity • tetrahydrobiopterin biosynthetic process • oxidation-reduction process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6697	20751
Ensembl	ENSG00000116096	ENSMUSG00000033735
UniProt	P35270	Q64105
RefSeq (mRNA)	NM_003124	NM_011467
RefSeq (protein)	NP_003115	n/a
Location (UCSC)	Chr 2: 72.89 – 72.89 Mb	Chr 6: 85.13 – 85.14 Mb
PubMed search

sepiapterin reductase
Identifiers
EC number	1.1.1.153
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

Search
PMC	articles
PubMed	articles
NCBI	proteins

1Z6Z, 4HWK, 4J7U, 4J7X, 4XWY, 4Z3K

6697

20751

ENSG00000116096

ENSMUSG00000033735

P35270

Q64105

NM_003124

NM_011467

NP_003115

n/a

Sepiapterin reductase is an enzyme that in humans is encoded by the SPR gene.

Sepiapterin reductase (7,8-dihydrobiopterin:NADP⁺ oxidoreductase; EC 1.1.1.153) catalyzes the NADPH-dependent reduction of various carbonyl substances, including derivatives of pteridines, and belongs to a group of enzymes called aldo-keto reductases. SPR plays an important role in the biosynthesis of tetrahydrobiopterin.

Sepiapterin reductase (SPR) catalyzes the chemical reaction

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Wikipedia