Spencer was drafted out of the University of Washington, where he played college baseball for the Huskies from 1994–1995, by his hometown Seattle Mariners in the 40th round of the 1996 Major League Baseball draft. He made his major league debut with the Mariners on May 6, 1999, pitching 1/3 of an inning and giving up 2 earned runs against the Cleveland Indians. On August 10, 2000, Spencer was announced as the first of two PTBNLs traded to the Montreal Expos for Chris Widger. In 8 games for Montreal, he struck out 6 and had an ERA of 5.40. The Expos released him on July 19, 2002. On July 25, 2003, Spencer signed a minor league contract with the Baltimore Orioles and pitched in the minors for them until his retirement after the 2004 season.

Spencer played for Greece in the 2004 Summer Olympics in Athens, Greece.

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