"Screaming Bloody Murder" is the first single from Sum 41's fifth studio album of the same name, officially released on February 7, 2011, although originally slated for release in August 2010. The song's working title was "Panic Attack" and it was written by the band's guitarist Tom Thacker for the album Muertos Vivos by his other band Gob, though it did not make the album, then reworked, rearranged and re-recorded by guitarist Deryck Whibley. Although written by Thacker, all guitars on the song, as well as on the rest of the album were recorded by Deryck Whibley by himself.

On January 8, 2011, it was announced that the band will release the single "Screaming Bloody Murder" on February 8, 2011, in the United States, the band's first single in 3 years. It was released a day earlier, on February 7, in Europe. The song was released as a digital download only on iTunes, Amazon.com and other music retailers, with no intention to release it as a physical CD single. The song had its worldwide premiere, a month before the official release, on January 13, 2011, on the Detroit area radio station 89X. It then premiered on AOL Radio, a few hours later the same day. "Screaming Bloody Murder" was released to radio on February 8, 2011.

The band performed the song live for the first time on February 4, 2011, in Paris, France, the first date of their first official European leg of the Screaming Bloody Murder Tour. It has since been performed live on every show.

The song "Screaming Bloody Murder" was performed on Jimmy Kimmel Live! on March 31, 2011. "Screaming Bloody Murder" was also performed on Lopez Tonight on April 14, 2011.

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