Scipione Gonzaga (11 November 1542 – 11 January 1593) was an Italian cardinal.
Born in Mantua, he belonged to the family of the Dukes of Sabbioneta, passed his youth under the care of Cardinal Ercole Gonzaga, and made rapid progress in Greek and Latin studies. At Bologna, and later at Padua, he studied mathematics and philosophy, and, in the latter city, founded the Accademia degli Eterei, or Academy of the Ethereals. Throughout his life he patronized literature and men of letters, among the latter being Tasso, who sought his advice concerning his Gerusalemme Liberata, and Guarino, who dedicated to him his Pastor Fido. Gonzaga's home in Rome, the Palazzo Aragona Gonzaga, was a meeting place for the most eminent musicians and intellectuals of the day.
Having finished his theological studies he went to Rome, became cameriere segreto to Pope Pius IV, and was ordained priest. In the early years of the reign of Pope Gregory XIII Gonzaga had a serious lawsuit with the Duke of Mantua over some property, but they were soon reconciled. Through the Guise party, whose cause he had aided, he became Bishop of Mende in France, but Charles, Duke of Guise pleaded unsuccessfully with Gregory XIII to have him made cardinal. On 4 Oct 1585, he was consecrated bishop by Iñigo Avalos de Aragón, Cardinal-Priest of San Lorenzo in Lucina, with Enrico Caetani, Titular Patriarch of Alexandria, and Annibale de Capua, Archbishop of Naples, serving as co-consecrators.