Sayō (佐用郡 Sayō-gun?) is a district located in Hyōgo Prefecture, Japan.
As of 2003, the district has an estimated population of 21,614 and a density of 70.29 persons per km². The total area is 307.51 km².
On October 1, 2005 the towns of Kōzuki, Mikazuki and Nankō merged into the town of Sayō.
Coordinates: 35°01′05″N 134°22′19″E / 35.018°N 134.372°E