"Save Me" is a song by American rock band Shinedown. The song was released as the first single in promotion of the band's second studio album, Us and Them. "Save Me" was the theme song for WWE's No Mercy 2005 pay-per-view event, and is their second most commercially successful single to date, reaching number one on the U.S. mainstream rock chart (and remaining there for 12 weeks). It is also Shinedown's third-highest charting song on the Billboard Hot 100 (behind "Second Chance" (number 7) and "If You Only Knew" (number 42), peaking at number 72.

The foundations of the song came around when the band's singer, Brent Smith, was just 15 years old and beginning to make demo tracks.

At the time the single was released to radio, the band was still working to complete the album which had not yet been mixed or mastered. According to Brent Smith, "when the first single, 'Save Me', hit the radio, I still hadn't written lyrics for four of the songs nor had sung four others on the album. I was in the studio working my ass off to get finished".

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