Sathyavani Muthu (15 February 1923 – 11 November 1999) was an Indian politician and an influential leader from Chennai, Tamil Nadu. She was a Member of the Legislative Assembly of Tamil Nadu, Rajya Sabha member and Union Minister. She began her political career as a member of Dravida Munnetra Kazhagam, began her own party, Thazhthapattor Munnetra Kazhagam and later joined the Anna Dravida Munnetra Kazhagam.
She was a member of Dravida Munnetra Kazhagam (DMK) since its beginning in 1949. In 1953, she was arrested for leading the DMK's protests against the Kula Kalvi Thittam. During 1959-58, she was the propaganda secretary of the party. She also served as the editor of the magazine Annai (lit. mother) She contested assembly elections from Perambur and Ulundurpet constituencies in all assembly elections between 1957 and 1977 and 1984. She won three times from Perambur constituency as an Independent candidate in 1957 election, as a Dravida Munnetra Kazhagam candidate in 1967, and 1971 elections. She lost the 1962 election from Perambur and 1977 election from Ulundurpet constituency.