Santiago, officially the Municipality of Santiago (Cebuano: Lungsod sa Santiago; Filipino: Bayan ng Santiago), is a municipality in the province of Agusan del Norte in the Caraga (Region XIII) of the Philippines. The population was 24,200 at the 2015 census. In the 2016 electoral roll, it had 11,095 registered voters.

In the later part of 1898, a group of natives fleeing from the municipality of Jabonga settled in a place recognized by the municipality of Cabadbaran as barrio Santiago, However, in 1924 the Aciga River swelled its banks, destroying all properties, crops and animals along it. This forced the inhabitants of Santiago, Cabadbaran to transfer to barrio Jagupit. In 1936, the same Aciga River wrought extensive damage which made the inhabitants decide to transfer at the foot of the hill, particularly at Sitio Paypay, which was inhabited by two groups of natives-the Manobos and the Mamanwas, then.

The construction of the national highway, which passes thru sitio Paypay, lured more people to settle in the place.

On April 26, 1959, the name Paypay was changed to Santiago through Republic Act 2170, in honor of Senior Santiago or Saint James.

In 1964, the barrio officials of Santiago indicated their desire to become a separate municipality. Finally, on June 15, 1968, the barrios of Santiago and Jagupit were separated from Cabadbaran and constituted into the new municipality of Santiago, through Republic Act 5242.

Santiago is located at 9°16′N 125°34′E / 9.27°N 125.56°E / 9.27; 125.56.

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