Coordinates: 41°53′27.81″N 12°28′3.31″E / 41.8910583°N 12.4675861°E
Santa Maria della Scala (Italian: Holy Mary of the Staircase) is a titular church in Rome, Italy, located in the Trastevere rione.
Cardinal Ernest Simoni will take possession of the titular church on February 11, 2017.
The church was built between 1593 and 1610 to honor a miraculous icon of the Madonna. Tradition holds that the icon, when placed on the landing of a staircase of a neighboring house of a mother who prayed before it, had cured her deformed child. Consecrated to Mary, mother of Jesus, it enshrines that icon in the north transept, alongside a baroque statue of St John of the Cross. It was sited adjacent to a monastery famous for containing the Papal court's 17th century pharmacy (its furnishings and equipment has been preserved). In 1650, nearly fifty years after the buildings completion, Carlo Rainaldi designed for the church a tempietto-shaped baldachino with 16 slender jasper Corinthian columns and a high altar.
In 1849, during the last stages of the revolutionary Roman Republic's resistance to the invading French forces, Santa Maria della Scala was used as a hospital where Garibaldi's soldiers, wounded in the Trastevere fighting, were treated.