Sanatana Goswami (1488–1558) was a principal disciple of Chaitanya Mahaprabhu. Sanatana wrote a number of important works in the bhakti tradition of Gaudiya Vaishnavism and was the seniormost of the influential Six Goswamis of Vrindavan, among whom was his brother Rupa Goswami.
Sanatana was born in Jessore, now in Bangladesh, in 1488 as the son of Mukunda, the private secretary of the Sultan of Bengal, Jalaluddin Fateh Shah (ruled 1481–1487). Sanatana was the eldest son of Mukunda, and his younger brothers were Rupa and Vallabha (Anupama).
Sanatana and his brothers studied Nyaya (rhetortic) and Vedanta from the famous logician Vasudeva Sarvabhauma Bhattacharya. They also studied under Sarvabhauma's brother, Madhusudana Vidyavacaspati, from whom Sanatana took initiation in his childhood.
On the death of his father, Sanatana was forced to take up the post of Sakara Mallik (treasurer) to the new ruler of Bengal, Alauddin Hussein Shah (ruled 1493–1519), while his brother Rupa was given the post of Dabir-i-khas (private secretary).
Sanatana and Rupa received land from the government for their personal use in Fatehabad, where they built a huge palace. They also built several mansions at Ramakeli. It was at Ramakeli in 1513 that Sanatana and his two brothers met Chaitanya Mahaprabhu for the first time. After meeting them, Chaitanya gave them the names Rupa, Sanatana and Anupama. Due to this meeting, the brothers decided to renounce the world and join Chaitanya and his entourage. Rupa resigned from his post, but Sanatana’s resignation was refused by the Sultan. Sanatana stopped coming to court and feigned sickness. But when the Sultan sent his personal physicians to treat Sanatana they returned and reported that Sanatana was in perfectly good health. The Sultan personally visited Sanatana and tried to convince him to continue to render his governmental duties and accompany him on a military campaign against the neighbouring state of Odisha. Upon Sanatana’s refusal, Hussein Shah had him thrown into prison.