The community of San Antonio Valley, also called San Antonio or San Antone, is located along the Diablo Range in eastern Santa Clara County, California. The locale is bordered by Alameda County to the north and Stanislaus County to the east. The sparsely populated area is located at the junction of San Antonio Valley Road, Mines Road, and Del Puerto Canyon Road. The area includes the San Antonio Valley Ecological Reserve, a 3,282 acre nature preserve created by a Nature Conservancy purchase of land from local rancher, Keith Hurner, and known for its herd of tule elk.
The San Antonio Valley appears to have been a transitional area between the native Ohlone cultures from the San Francisco-Monterey region and the Yokut of the San Joaquin River watershed. The Ohlone are speculated to have arrived in the Bay Area around 500 A.D. when they displaced Hokan speaking populations already in the region.
On April 5, 1776, the de Anza Expedition called the area El Cañada de San Vicente. The 1956 Thomas Brothers map spells it San Antone. This spelling mimics the way it is pronounced in common, modern usage by locals. It was spelled San Antone on the 1924 "Mount Boardman, California" U.S. Geological Survey 15-minute quadrangle.
La Vereda del Monte traversed the valley on its way between the Sacramento River Delta and the Central Valley and was used by Joaquin Murrieta to transport stolen horses.
The U.S. Postal Service established a Deforest Post Office in the area during 1892. It was moved within the area in 1897, 1906, and finally closed in 1909. Another 1924 map calls a group of buildings along San Antonio Creek, Deforest. The name comes from Ransford S. Deforest, the first Postmaster in the community.