Sakamoto-shuku (坂本宿 Sakamoto-shuku?) was the seventeenth of the sixty-nine stations of the Nakasendō. It is located in the present-day city of Annaka, Gunma Prefecture, Japan.
Sakamoto-shuku is located at the eastern entrance to the Usui Pass. During the Edo period, there were a total of four honjin and sub-honjin combined. There were an additional 40 other buildings for travelers to use, making it a comparatively large station along the Nakasendō.
Coordinates: 36°20′59″N 138°43′03″E / 36.3498°N 138.7175°E