SYT1

SYT1

Protein SYT1 PDB 1byn.png

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2K45, 2K4A, 2K8M, 2KI6, 2LHA, 2N1T, 2R83, 3F00, 3F01, 3F04, 3F05, 4ISQ, 4V11

Identifiers

SYT1, P65, SVP65, SYT, synaptotagmin 1

External IDs

MGI: 99667 HomoloGene: 4122 GeneCards: SYT1

Genetically Related Diseases

Gene ontology
Molecular function	• protein C-terminus binding • metal ion binding • phosphatidylinositol-4,5-bisphosphate binding • calcium ion binding • clathrin binding • identical protein binding • calcium-dependent protein binding • phospholipid binding • SNARE binding • calmodulin binding • 1-phosphatidylinositol binding • phosphatidylserine binding • low-density lipoprotein particle receptor binding • syntaxin binding • protein binding • syntaxin-1 binding • calcium-dependent phospholipid binding • syntaxin-3 binding • protein heterodimerization activity
Cellular component	• terminal bouton • SNARE complex • clathrin-sculpted glutamate transport vesicle membrane • intracellular organelle • cytoplasm • transport vesicle membrane • synapse • integral component of membrane • Golgi apparatus • cell junction • clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane • presynaptic membrane • dense core granule • clathrin-sculpted monoamine transport vesicle membrane • neuron projection • chromaffin granule membrane • membrane • excitatory synapse • synaptic vesicle • secretory granule • clathrin-sculpted acetylcholine transport vesicle membrane • cytoplasmic vesicle • synaptic vesicle membrane • plasma membrane • integral component of synaptic vesicle membrane • axon • clathrin-coated vesicle membrane • neuron projection terminus
Biological process	• detection of calcium ion • positive regulation of vesicle fusion • chemical synaptic transmission • synaptic vesicle exocytosis • positive regulation of calcium ion-dependent exocytosis • response to calcium ion • regulation of regulated secretory pathway • brain development • glutamate secretion • positive regulation of dendrite extension • positive regulation of synaptic transmission • regulation of synaptic transmission, glutamatergic • regulation of exocytosis • synaptic vesicle endocytosis • vesicle docking • cell differentiation • fast, calcium ion-dependent exocytosis of neurotransmitter • neurotransmitter secretion • cellular response to calcium ion • vesicle fusion • regulation of calcium ion-dependent exocytosis • calcium ion-regulated exocytosis of neurotransmitter • regulation of dopamine secretion • protein homooligomerization • protein heterooligomerization • membrane organization
Sources:Amigo / QuickGO

RNA expression pattern

PBB GE SYT1 203998 s at fs.png

PBB GE SYT1 203999 at fs.png

More reference expression data

Orthologs

Species

Human

Mouse


6857


20979


ENSG00000067715


ENSMUSG00000035864


P21579


P46096

RefSeq (mRNA)


NM_001135805 NM_001135806 NM_001291901 NM_005639


NM_001252341 NM_001252342 NM_009306

RefSeq (protein)


NP_001129277 NP_001129278 NP_001278830 NP_005630

NP_001239270.1 NP_001239271.1 NP_033332.1 NP_001239270 NP_001239271
NP_033332

Location (UCSC)

Chr 12: 78.86 – 79.45 Mb

Chr 10: 108.5 – 109.01 Mb

PubMed search

2K45, 2K4A, 2K8M, 2KI6, 2LHA, 2N1T, 2R83, 3F00, 3F01, 3F04, 3F05, 4ISQ, 4V11

ENSG00000067715

ENSMUSG00000035864

NM_001135805
NM_001135806
NM_001291901
NM_005639

...
Wikipedia

...