SUV39H1

SUV39H1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3MTS
Identifiers
Aliases	SUV39H1, H3-K9-HMTase 1, KMT1A, MG44, SUV39H, suppressor of variegation 3-9 homolog 1
External IDs	MGI: 1099440 HomoloGene: 2388 GeneCards: SUV39H1
Gene ontology Molecular function • methyltransferase activity • transferase activity • histone methyltransferase activity • histone methyltransferase activity (H3-K9 specific) • S-adenosylmethionine-dependent methyltransferase activity • protein N-terminus binding • zinc ion binding • chromatin binding • transcription regulatory region sequence-specific DNA binding • metal ion binding • protein binding • histone-lysine N-methyltransferase activity Cellular component • nuclear lamina • nucleoplasm • chromosome • heterochromatin • condensed nuclear chromosome • rDNA heterochromatin • chromatin silencing complex • chromosome, centromeric region • nucleus Biological process • cell differentiation • regulation of transcription, DNA-templated • histone H3-K9 dimethylation • rhythmic process • negative regulation of circadian rhythm • negative regulation of transcription from RNA polymerase II promoter • chromatin organization • transcription, DNA-templated • histone H3-K9 trimethylation • cellular response to DNA damage stimulus • methylation • chromatin silencing at rDNA • rRNA processing • histone lysine methylation • cell cycle • viral process • negative regulation of transcription, DNA-templated • cellular response to hypoxia • covalent chromatin modification Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6839	20937
Ensembl	ENSG00000101945	ENSMUSG00000039231
UniProt	O43463	O54864
RefSeq (mRNA)	NM_003173 NM_001282166	NM_001290716 NM_011514
RefSeq (protein)	NP_001269095 NP_003164	NP_001277645.1 NP_035644.1 NP_001277645 NP_035644
Location (UCSC)	Chr X: 48.7 – 48.71 Mb	Chr X: 8.06 – 8.07 Mb
PubMed search

3MTS

6839

20937

ENSG00000101945

ENSMUSG00000039231

O43463

O54864

NM_003173
NM_001282166

NM_001290716
NM_011514

NP_001269095
NP_003164

NP_001277645.1
NP_035644.1
NP_001277645
NP_035644

Histone-lysine N-methyltransferase SUV39H1 is an enzyme that in humans is encoded by the SUV39H1 gene.

This gene is a member of the suppressor of variegation 3-9 homolog family and encodes a protein with a chromodomain and a C-terminal SET domain. This nuclear protein moves to the centromeres during mitosis and functions as a histone methyltransferase, methylating Lys-9 of histone H3. Overall, it plays a vital role in heterochromatin organization, chromosome segregation, and mitotic progression.

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