SUR1

ABCC8
Identifiers
Aliases	ABCC8, ABC36, HHF1, HI, HRINS, MRP8, PHHI, SUR, SUR1, SUR1delta2, TNDM2, ATP binding cassette subfamily C member 8
External IDs	MGI: 1352629 HomoloGene: 68048 GeneCards: ABCC8
Gene ontology Molecular function • nucleotide binding • potassium channel activity • ion channel binding • sulfonylurea receptor activity • ATPase activity • syntaxin binding • ATP binding • ATPase-coupled anion transmembrane transporter activity • ATP-activated inward rectifier potassium channel activity • ATPase activity, coupled to transmembrane movement of substances Cellular component • integral component of membrane • membrane • voltage-gated potassium channel complex • plasma membrane • synaptic vesicle membrane • sarcolemma • mitochondrion • ATP-sensitive potassium channel complex Biological process • cellular response to organic substance • negative regulation of insulin secretion • regulation of insulin secretion • positive regulation of potassium ion transport • response to zinc ion • response to insulin • potassium ion transport • response to lipopolysaccharide • transmembrane transport • response to pH • signal transduction • potassium ion transmembrane transport • ATP hydrolysis coupled anion transmembrane transport • response to drug • positive regulation of uterine smooth muscle relaxation • positive regulation of voltage-gated potassium channel activity • cellular glucose homeostasis • female pregnancy • negative regulation of low-density lipoprotein particle clearance • negative regulation of neurogenesis • negative regulation of glial cell proliferation • negative regulation of neuroblast migration • memory • visual learning • negative regulation of angiogenesis • positive regulation of tumor necrosis factor production • negative regulation of wound healing • positive regulation of occluding junction disassembly • negative regulation of maintenance of permeability of blood-brain barrier • transport Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6833	20927
Ensembl	ENSG00000006071	ENSMUSG00000040136
UniProt	Q09428	n/a
RefSeq (mRNA)	NM_000352 NM_001287174 NM_001351295 NM_001351296 NM_001351297	NM_011510
RefSeq (protein)	NP_000343 NP_001274103 NP_001338224 NP_001338225 NP_001338226	n/a
Location (UCSC)	Chr 11: 17.39 – 17.48 Mb	Chr 7: 46.1 – 46.18 Mb
PubMed search

6833

20927

ENSG00000006071

ENSMUSG00000040136

Q09428

n/a

NM_000352
NM_001287174
NM_001351295
NM_001351296
NM_001351297

NM_011510

NP_000343
NP_001274103
NP_001338224
NP_001338225
NP_001338226

n/a

ATP-binding cassette transporter sub-family C member 8 is a protein that in humans is encoded by the ABCC8 gene.ABCC8 orthologs have been identified in all mammals for which complete genome data are available.

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Wikipedia