SULF2

SULF2
Identifiers
Aliases	SULF2, HSULF-2, sulfatase 2
External IDs	MGI: 1919293 HomoloGene: 10313 GeneCards: SULF2
Gene ontology Molecular function • calcium ion binding • arylsulfatase activity • metal ion binding • catalytic activity • sulfuric ester hydrolase activity • hydrolase activity • N-acetylglucosamine-6-sulfatase activity Cellular component • Golgi apparatus • plasma membrane • cell surface • endoplasmic reticulum • Golgi stack • extracellular space Biological process • glomerular basement membrane development • kidney development • positive regulation of canonical Wnt signaling pathway • positive regulation of catenin import into nucleus • chondrocyte development • embryonic skeletal system development • positive regulation of Wnt signaling pathway • negative regulation of fibroblast growth factor receptor signaling pathway • liver regeneration • cartilage development • glomerular filtration • response to wounding • regulation of hepatocyte proliferation • glial cell-derived neurotrophic factor receptor signaling pathway • positive regulation of vascular endothelial growth factor production • metabolic process • esophagus smooth muscle contraction • innervation • bone development • heparan sulfate proteoglycan metabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55959	72043
Ensembl	ENSG00000196562	ENSMUSG00000006800
UniProt	Q8IWU5	Q8CFG0
RefSeq (mRNA)	NM_001161841 NM_018837 NM_198596	NM_001252578 NM_001252579 NM_028072
RefSeq (protein)	NP_001155313 NP_061325 NP_940998	NP_001239507 NP_001239508 NP_082348
Location (UCSC)	Chr 20: 47.66 – 47.79 Mb	Chr 2: 166.07 – 166.16 Mb
PubMed search

55959

72043

ENSG00000196562

ENSMUSG00000006800

Q8IWU5

Q8CFG0

NM_001161841
NM_018837
NM_198596

NM_001252578
NM_001252579
NM_028072

NP_001155313
NP_061325
NP_940998

NP_001239507
NP_001239508
NP_082348

Extracellular sulfatase Sulf-2 is an enzyme that in humans is encoded by the SULF2 gene.

Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005).[supplied by OMIM]

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Wikipedia