STARD8

STARD8
Identifiers
Aliases	STARD8, ARHGAP38, DLC3, STARTGAP3, StAR related lipid transfer domain containing 8
External IDs	MGI: 2448556 HomoloGene: 22837 GeneCards: STARD8
Gene ontology Molecular function • lipid binding • GTPase activator activity Cellular component • cytosol • cell junction • focal adhesion Biological process • positive regulation of GTPase activity • regulation of small GTPase mediated signal transduction • signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9754	236920
Ensembl	ENSG00000130052	ENSMUSG00000031216
UniProt	Q92502	Q8K031
RefSeq (mRNA)	NM_001142503 NM_001142504 NM_014725	NM_199018
RefSeq (protein)	NP_001135975 NP_001135976 NP_055540	NP_950183
Location (UCSC)	Chr X: 68.65 – 68.73 Mb	Chr X: 99 – 99.07 Mb
PubMed search

9754

236920

ENSG00000130052

ENSMUSG00000031216

Q92502

Q8K031

NM_001142503
NM_001142504
NM_014725

NM_199018

NP_001135975
NP_001135976
NP_055540

NP_950183

StAR-related lipid transfer domain protein 8 (STARD8) also known as deleted in liver cancer 3 protein (DLC-3) is a protein that in humans is encoded by the STARD8 gene and is a member of the DLC family.

The protein is 1103 amino acids long, which like other DLC proteins consists of a sterile alpha motif (SAM), RhoGAP and a StAR-related lipid-transfer (START) domains.

The protein is a Rho GTPase-activating protein (GAP), a type of protein that regulates members of the Rho family of GTPases. STARD8 is characterized as activating Rho GTPases. Its expression inhibits the growth of human breast and prostate cancer cells in culture.

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Wikipedia