STARD3NL

STARD3NL
Identifiers
Aliases	STARD3NL, MENTHO, STARD3 N-terminal like
External IDs	MGI: 1923455 HomoloGene: 11501 GeneCards: STARD3NL
Gene location (Human) Chr. Chromosome 7 (human) Band 7p14.1 Start 38,178,222 bp End 38,230,671 bp
Gene location (Mouse) Chr. Chromosome 13 (mouse) Band 13|13 A2 Start 19,357,676 bp End 19,395,795 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • protein binding • cholesterol binding • protein homodimerization activity Cellular component • lysosomal membrane • membrane • integral component of membrane • endosome • cytosol • intracellular membrane-bounded organelle • endoplasmic reticulum membrane • late endosome membrane • organelle membrane contact site Biological process • C21-steroid hormone biosynthetic process • vesicle tethering to endoplasmic reticulum Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	83930	76205
Ensembl	ENSG00000010270	ENSMUSG00000003062
UniProt	O95772	Q9DCI3
RefSeq (mRNA)	NM_032016	NM_024270 NM_001347485
RefSeq (protein)	NP_114405	NP_001334414 NP_077232
Location (UCSC)	Chr 7: 38.18 – 38.23 Mb	Chr 13: 19.36 – 19.4 Mb
PubMed search

83930

76205

ENSG00000010270

ENSMUSG00000003062

O95772

Q9DCI3

NM_032016

NM_024270
NM_001347485

NP_114405

NP_001334414
NP_077232

MENTHO or STARD3 N-terminal like protein (STARD3NL) is an integral membrane protein of unknown function. As the alternate name implies, MENTHO, short for "MLN64 N-terminal homologue", contains a region in its N-terminus similar to that found in STARD3, also known as MLN64, but lacks the StAR-related transfer domain (START) that characterizes all other proteins given the "STARD" (START domain-containing) name. The N-terminal domain is called a MENTAL (MLN64 N-terminal) domain.

Like MLN64, MENTHO is widely expressed in tissues of the body. Within the cell, it localizes to the membranes of late endosomes and may interact there with MLN64. It is suggested that in combination with MLN64, this protein helps regulate the flow of cholesterol through the endosomal pathway.

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Wikipedia