SRGAP2

SRGAP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4RTT, 4RUG, 2DL8
Identifiers
Aliases	SRGAP2, ARHGAP34, FNBP2, SRGAP2A, SRGAP3, SLIT-ROBO Rho GTPase activating protein 2
External IDs	MGI: 109605 HomoloGene: 52683 GeneCards: SRGAP2
Gene location (Human) Chr. Chromosome 1 (human) Band 1q32.1 Start 206,203,345 bp End 206,464,443 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 E4 Start 131,285,251 bp End 131,527,352 bp
Gene ontology Molecular function • Rac GTPase binding • protein homodimerization activity • protein binding • GTPase activator activity • identical protein binding Cellular component • cytoplasm • cytosol • postsynaptic membrane • cell projection • membrane • postsynaptic density • dendritic spine • synapse • cell junction • dendritic spine head • phagocytic vesicle • cytoplasmic vesicle • nucleus • lamellipodium • plasma membrane • nucleoplasm Biological process • lamellipodium assembly involved in ameboidal cell migration • negative regulation of neuron migration • neuron projection morphogenesis • actin filament severing • filopodium assembly • negative regulation of cell death • nervous system development • dendritic spine development • substrate adhesion-dependent cell spreading • extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration • cell proliferation • regulation of small GTPase mediated signal transduction • signal transduction • positive regulation of GTPase activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23380	14270
Ensembl	ENSG00000266028	ENSMUSG00000026425
UniProt	O75044	Q91Z67
RefSeq (mRNA)	NM_001042758 NM_001170637 NM_001300952 NM_015326	NM_001081011 NM_019520
RefSeq (protein)	NP_001164108 NP_001287881 NP_056141	NP_001074480
Location (UCSC)	Chr 1: 206.2 – 206.46 Mb	Chr 1: 131.29 – 131.53 Mb
PubMed search

4RTT, 4RUG, 2DL8

23380

14270

ENSG00000266028

ENSMUSG00000026425

O75044

Q91Z67

NM_001042758
NM_001170637
NM_001300952
NM_015326

NM_001081011
NM_019520

NP_001164108
NP_001287881
NP_056141

NP_001074480

SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) also known as formin-binding protein 2 (FNBP2) is a protein that in humans is encoded by the SRGAP2 gene.

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Wikipedia