SRC-3

NCOA3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1KBH, 3L3X, 3L3Z
Identifiers
Aliases	NCOA3, ACTR, AIB-1, AIB1, CAGH16, CTG26, KAT13B, RAC3, SRC-3, SRC3, TNRC14, TNRC16, TRAM-1, bHLHe42, pCIP, nuclear receptor coactivator 3
External IDs	MGI: 1276535 HomoloGene: 4764 GeneCards: NCOA3
Gene location (Human) Chr. Chromosome 20 (human) Band 20q13.12 Start 47,501,902 bp End 47,656,877 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 H3 Start 165,992,636 bp End 166,073,242 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • transferase activity • protein dimerization activity • protein N-terminus binding • transcription coactivator activity • nuclear hormone receptor binding • thyroid hormone receptor binding • histone acetyltransferase activity • protein binding • androgen receptor binding • ligand-dependent nuclear receptor binding • ligand-dependent nuclear receptor transcription coactivator activity • transferase activity, transferring acyl groups • protein heterodimerization activity • disordered domain specific binding • RNA polymerase II core binding Cellular component • cytoplasm • nucleoplasm • nuclear chromatin • extracellular exosome • nucleus • cytosol • protein complex Biological process • androgen receptor signaling pathway • regulation of RNA biosynthetic process • regulation of transcription, DNA-templated • positive regulation of keratinocyte differentiation • cellular response to estradiol stimulus • transcription, DNA-templated • positive regulation of transcription, DNA-templated • positive regulation of gene expression • positive regulation of transcription from RNA polymerase II promoter • receptor transactivation • intracellular receptor signaling pathway • histone acetylation • cellular response to hormone stimulus • cell dedifferentiation • positive regulation of stem cell population maintenance • regulation of stem cell division Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	8202	17979
Ensembl	ENSG00000124151	ENSMUSG00000027678
UniProt	Q9Y6Q9	O09000
RefSeq (mRNA)	NM_181659 NM_001174087 NM_001174088 NM_006534	NM_008679
RefSeq (protein)	NP_001167558 NP_001167559 NP_006525 NP_858045	n/a
Location (UCSC)	Chr 20: 47.5 – 47.66 Mb	Chr 20: 165.99 – 166.07 Mb
PubMed search

1KBH, 3L3X, 3L3Z

8202

17979

ENSG00000124151

ENSMUSG00000027678

Q9Y6Q9

O09000

NM_181659
NM_001174087
NM_001174088
NM_006534

NM_008679

NP_001167558
NP_001167559
NP_006525
NP_858045

n/a

The nuclear receptor coactivator 3 also known as NCOA3 is a protein that, in humans, is encoded by the NCOA3 gene. NCOA3 is also frequently called 'amplified in breast 1' (AIB1), steroid receptor coactivator-3 (SRC-3), or thyroid hormone receptor activator molecule 1 (TRAM-1).

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