SPI1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1PUE

Identifiers

Aliases

SPI1, OF, PU.1, SFPI1, SPI-1, SPI-A, Spi-1 proto-oncogene

External IDs

MGI: 98282 HomoloGene: 2346 GeneCards: SPI1

Gene ontology
Molecular function	• DNA binding • sequence-specific DNA binding • core promoter binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding • transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding • protein binding • RNA binding • RNA polymerase II transcription factor activity, sequence-specific DNA binding • RNA polymerase II core promoter sequence-specific DNA binding • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • RNA polymerase II transcription factor binding • RNA polymerase II distal enhancer sequence-specific DNA binding • transcription factor activity, sequence-specific DNA binding • NFAT protein binding
Cellular component	• nucleus • nuclear chromatin • nucleoplasm
Biological process	• myeloid leukocyte differentiation • regulation of transcription, DNA-templated • cellular response to ethanol • somatic stem cell population maintenance • lymphocyte differentiation • regulation of erythrocyte differentiation • myeloid dendritic cell differentiation • negative regulation of transcription from RNA polymerase II promoter • negative regulation of MHC class II biosynthetic process • transcription from RNA polymerase II promoter • lymphoid progenitor cell differentiation • transcription, DNA-templated • macrophage differentiation • anatomical structure regression • negative regulation of histone H4 acetylation • negative regulation of gene expression, epigenetic • vasculature development • granulocyte differentiation • apoptotic process involved in blood vessel morphogenesis • histone H3 acetylation • erythrocyte differentiation • hypermethylation of CpG island • positive regulation of pri-miRNA transcription from RNA polymerase II promoter • positive regulation of transcription from RNA polymerase II promoter • negative regulation of transcription, DNA-templated • positive regulation of transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


6688


20375

Ensembl


ENSG00000066336


ENSMUSG00000002111

UniProt


P17947


P17433

RefSeq (mRNA)


NM_001080547 NM_003120


NM_011355

RefSeq (protein)


NP_001074016 NP_003111


NP_035485.1 NP_035485

Location (UCSC)

Chr 11: 47.35 – 47.38 Mb

Chr 2: 91.08 – 91.12 Mb

PubMed search

NM_001080547
NM_003120

NM_011355

NP_001074016
NP_003111

NP_035485.1
NP_035485

Transcription factor PU.1 is a protein that in humans is encoded by the SPI1 gene.

This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development.[Citation needed] The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different isoforms have been found for this gene.

SPI1 has been shown to interact with:

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Wikipedia