SPHK1

SPHK1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
3VZB, 3VZC, 3VZD, 4L02, 4V24

Identifiers

SPHK1, SPHK, sphingosine kinase 1

External IDs

OMIM: 603730 MGI: 1316649 HomoloGene: 39748 GeneCards: SPHK1

Gene ontology
Molecular function	• sphingosine-1-phosphate receptor activity • transferase activity • nucleotide binding • DNA binding • calmodulin binding • kinase activity • protein binding • protein phosphatase 2A binding • ATP binding • magnesium ion binding • sphinganine kinase activity • D-erythro-sphingosine kinase activity
Cellular component	• cytoplasm • membrane • plasma membrane • nucleus • cytosol
Biological process	• intracellular signal transduction • positive regulation of fibroblast proliferation • sphingosine metabolic process • regulation of tumor necrosis factor-mediated signaling pathway • sphingosine biosynthetic process • positive regulation of mitotic cell cycle • sphingolipid biosynthetic process • positive regulation of angiogenesis • positive regulation of cell growth • brain development • blood vessel development • positive regulation of NF-kappaB transcription factor activity • positive regulation of peptidyl-threonine phosphorylation • protein folding • positive regulation of cell proliferation • regulation of interleukin-1 beta production • positive regulation of NF-kappaB import into nucleus • inflammatory response • sphingoid catabolic process • positive regulation of protein ubiquitination • positive regulation of smooth muscle contraction • calcium-mediated signaling • signal transduction • sphingosine-1-phosphate signaling pathway • lipid phosphorylation • positive regulation of cell migration • negative regulation of apoptotic process • phosphorylation
Sources:Amigo / QuickGO

RNA expression pattern

PBB GE SPHK1 219257 s at tn.png

More reference expression data

Orthologs

Species

Human

Mouse


8877


20698


ENSG00000176170


ENSMUSG00000061878


Q9NYA1


Q8CI15

RefSeq (mRNA)


NM_001142601 NM_001142602 NM_021972 NM_182965


NM_001172472 NM_001172473 NM_001172475 NM_011451 NM_025367

RefSeq (protein)


NP_001136073 NP_001136074 NP_068807 NP_892010

NP_001165943.1 NP_001165944.1 NP_001165946.1 NP_035581.1 NP_079643.2
NP_001165943 NP_001165944 NP_001165946 NP_035581 NP_079643

Location (UCSC)

Chr 17: 76.38 – 76.39 Mb

Chr 11: 116.53 – 116.54 Mb

PubMed search

3VZB, 3VZC, 3VZD, 4L02, 4V24

ENSG00000176170

ENSMUSG00000061878

NM_001142601
NM_001142602
NM_021972
NM_182965

NM_001172472
NM_001172473
NM_001172475
NM_011451
NM_025367

NP_001136073
NP_001136074
NP_068807
NP_892010

...
Wikipedia

...