SPEN

SPEN
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1OW1, 2RT5, 4P6Q
Identifiers
Aliases	SPEN, HIAA0929, MINT, RBM15C, SHARP, spen family transcriptional repressor
External IDs	MGI: 1891706 HomoloGene: 124461 GeneCards: SPEN
Gene ontology Molecular function • DNA binding • protein binding • transcriptional repressor activity, RNA polymerase II transcription factor binding • RNA polymerase II transcription factor binding • nucleic acid binding • RNA binding Cellular component • transcriptional repressor complex • extracellular exosome • nucleus • nucleoplasm Biological process • Notch signaling pathway • positive regulation of neurogenesis • mRNA splicing, via spliceosome • viral process • negative regulation of transcription, DNA-templated • regulation of transcription, DNA-templated • negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23013	56381
Ensembl	ENSG00000065526	ENSMUSG00000040761
UniProt	Q96T58	Q62504
RefSeq (mRNA)	NM_015001	NM_019763 NM_001347235
RefSeq (protein)	NP_055816	NP_062737.2 NP_001334164 NP_062737
Location (UCSC)	Chr 1: 15.85 – 15.94 Mb	Chr 4: 141.47 – 141.54 Mb
PubMed search

1OW1, 2RT5, 4P6Q

23013

56381

ENSG00000065526

ENSMUSG00000040761

Q96T58

Q62504

NM_015001

NM_019763
NM_001347235

NP_055816

NP_062737.2
NP_001334164
NP_062737

Msx2-interacting protein is a protein that in humans is encoded by the SPEN gene.

This gene encodes a hormone inducible transcriptional repressor. Repression of transcription by this gene product can occur through interactions with other repressors, by the recruitment of proteins involved in histone deacetylation, or through sequestration of transcriptional activators. The product of this gene contains a carboxy-terminal domain that permits binding to other corepressor proteins. This domain also permits interaction with members of the NuRD complex, a nucleosome remodeling protein complex that contains deacetylase activity. In addition, this repressor contains several RNA recognition motifs that confer binding to a steroid receptor RNA coactivator; this binding can modulate the activity of both liganded and nonliganded steroid receptors.

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Wikipedia