SPATS1

Identifiers

Aliases

SPATS1, DDIP, SPATA8, SRSP1, spermatogenesis associated serine rich 1

External IDs

MGI: 1918270 HomoloGene: 12376 GeneCards: SPATS1

Orthologs

Species

Human

Mouse

Entrez


221409


71020

Ensembl


ENSG00000249481


ENSMUSG00000023935

UniProt


Q496A3


A2RRY8

RefSeq (mRNA)


NM_145026


NM_027649

RefSeq (protein)


NP_659463


NP_081925.2 NP_081925

Location (UCSC)

Chr 6: 44.34 – 44.38 Mb

Chr 17: 45.45 – 45.47 Mb

PubMed search

NP_081925.2
NP_081925

Spermatogenesis associated serine rich 1 (SPATS1) is a protein which in humans is encoded by the SPATS1 gene. It is also known by the aliases Dishevelled-DEP domain interacting protein (DDIP), Spermatogenesis Associated 8 (SPATA8), and serin-rich spermatogenic protein 1 (SRSP1). A general idea of its chemical structure, subcellular localization, expression, and conservation is known. Research suggests SPATS1 may play a role in the canonical Wnt Signaling pathway and in the first spermatogenic wave.

The human SPATS1 gene contains 1150 nucleotides, coding for 300 amino acids. It's located on the positive strand of chromosome 6 in the 21p1 region. As of now there are no known single nucleotide polymorphisms (SNPs) that prove to be clinically significant.

The protein in its longest form has 8 exons. There is another possible isoform, but experimental confirmation is lacking – possibly due to it being produced at low levels because of an immature stop codon. Bioinformatic analysis suggests that the protein does not have transmembrane structure and is composed of both alpha helixes and beta sheets. There have been conflicting numbers for SPATS1 isoelectric points. Several sources have said 6.68, while two others suggested that it is higher, 7.04 and 7.47.

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Wikipedia