SPAG6
| SPAG6 | |||||||||||||||||
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| Aliases | SPAG6, CT141, Repro-SA-1, pf16, sperm associated antigen 6 | ||||||||||||||||
| External IDs | MGI: 1354388 HomoloGene: 8252 GeneCards: SPAG6 | ||||||||||||||||
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| Species | Human | Mouse | |||||||||||||||
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| Location (UCSC) | Chr 10: 22.35 – 22.45 Mb | Chr 16: 16.75 – 16.83 Mb | |||||||||||||||
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NM_001253854
NM_001253855
NM_012443
NM_172242
NP_001240783
NP_001240784
NP_036575
NP_758442
Sperm-associated antigen 6 is a protein that in humans is encoded by the SPAG6 gene.
The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from an infertile man. This protein localizes to the tail of permeabilized human sperm and contains eight contiguous armadillo repeats, a motif known to mediate protein-protein interactions. Studies in mice suggest that this protein is involved in sperm flagellar motility and maintenance of the structural integrity of mature sperm. Alternatively spliced variants that encode different protein isoforms have been described but the full-length sequences of only two have been determined.
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Wikipedia