SOX4

SOX4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3U2B
Identifiers
Aliases	SOX4, EVI16, SRY-box 4
External IDs	MGI: 98366 HomoloGene: 2338 GeneCards: SOX4
Gene ontology Molecular function • DNA binding • RNA polymerase II transcription coactivator activity • transcription factor activity, sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • nucleic acid binding transcription factor activity • transcription regulatory region sequence-specific DNA binding • core promoter sequence-specific DNA binding • protein binding • protein heterodimerization activity • RNA polymerase II transcription factor activity, sequence-specific DNA binding Cellular component • cytoplasm • nuclear transcription factor complex • nucleoplasm • mitochondrion • nucleus Biological process • skeletal system development • noradrenergic neuron differentiation • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest • cardiac ventricle formation • glial cell development • regulation of transcription, DNA-templated • limb bud formation • regulation of protein stability • sympathetic nervous system development • somatic stem cell population maintenance • glucose homeostasis • positive regulation of canonical Wnt signaling pathway • ventricular septum morphogenesis • protein stabilization • ascending aorta morphogenesis • negative regulation of cell death • mitral valve morphogenesis • positive regulation of translation • transcription, DNA-templated • neuroepithelial cell differentiation • positive regulation of transcription, DNA-templated • positive regulation of Wnt signaling pathway • negative regulation of protein ubiquitination • heart development • pro-B cell differentiation • atrial septum primum morphogenesis • T cell differentiation • negative regulation of protein export from nucleus • kidney morphogenesis • positive regulation of cell proliferation • spinal cord development • positive regulation of apoptotic process • glial cell proliferation • canonical Wnt signaling pathway • positive regulation of N-terminal peptidyl-lysine acetylation • spinal cord motor neuron differentiation • cardiac right ventricle morphogenesis • neural tube formation • cellular response to glucose stimulus • endocrine pancreas development • negative regulation of cell proliferation • positive regulation of insulin secretion • positive regulation of transcription from RNA polymerase II promoter • DNA damage response, detection of DNA damage • transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6659	20677
Ensembl	ENSG00000124766	ENSMUSG00000076431
UniProt	Q06945	Q06831
RefSeq (mRNA)	NM_003107	NM_009238
RefSeq (protein)	NP_003098	NP_033264
Location (UCSC)	Chr 6: 21.59 – 21.6 Mb	Chr 13: 28.95 – 28.95 Mb
PubMed search

3U2B

6659

20677

ENSG00000124766

ENSMUSG00000076431

Q06945

Q06831

NM_003107

NM_009238

NP_003098

NP_033264

Transcription factor SOX-4 is a protein that in humans is encoded by the SOX4 gene.

This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin). The protein may function in the apoptosis pathway leading to cell death as well as to tumorigenesis and may mediate downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development. The solution structure has been resolved for the HMG-box of a similar mouse protein.

Sox4 is expressed in lymphocytes (B and T) and is required for B lymphocyte development.

SOX4 has been shown to interact with SDCBP.

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