SOX11

SOX11
Identifiers
Aliases	SOX11, MRD27, SRY-box 11
External IDs	MGI: 98359 HomoloGene: 37733 GeneCards: SOX11
Gene ontology Molecular function • DNA binding • RNA polymerase II transcription coactivator activity • transcription factor activity, sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • translation factor activity, RNA binding • transcription regulatory region sequence-specific DNA binding • enhancer sequence-specific DNA binding • RNA polymerase II core promoter sequence-specific DNA binding Cellular component • cytoplasm • nucleus Biological process • embryonic skeletal system morphogenesis • skeletal system development • noradrenergic neuron differentiation • positive regulation of lens epithelial cell proliferation • cell differentiation • cardiac ventricle formation • glial cell development • regulation of transcription, DNA-templated • limb bud formation • lung morphogenesis • sympathetic nervous system development • neural crest cell development • kidney development • negative regulation of glial cell proliferation • signal transduction involved in cell cycle checkpoint • soft palate development • ventricular septum morphogenesis • cornea development in camera-type eye • outflow tract morphogenesis • positive regulation of ossification • negative regulation of transcription from RNA polymerase II promoter • negative regulation of cell death • transcription from RNA polymerase II promoter • eyelid development in camera-type eye • negative regulation of gene expression • negative regulation of lymphocyte proliferation • somite development • transcription, DNA-templated • neuroepithelial cell differentiation • regulation of transforming growth factor beta receptor signaling pathway • nervous system development • positive regulation of transcription, DNA-templated • positive regulation of hippo signaling • positive regulation of neurogenesis • multicellular organism development • positive regulation of gene expression • positive regulation of osteoblast differentiation • lens morphogenesis in camera-type eye • negative regulation of transcription regulatory region DNA binding • hard palate development • positive regulation of neuron differentiation • neuron differentiation • positive regulation of cell proliferation • spinal cord development • positive regulation of BMP signaling pathway • glial cell proliferation • skeletal muscle cell differentiation • embryonic digestive tract morphogenesis • oligodendrocyte development • cell proliferation • positive regulation of stem cell proliferation • neural tube formation • positive regulation of hormone secretion • positive regulation of transcription from RNA polymerase II promoter • closure of optic fissure • translation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6664	20666
Ensembl	ENSG00000176887	ENSMUSG00000063632
UniProt	P35716	Q7M6Y2
RefSeq (mRNA)	NM_003108	NM_009234
RefSeq (protein)	NP_003099	NP_033260
Location (UCSC)	Chr 2: 5.69 – 5.7 Mb	Chr 12: 27.33 – 27.34 Mb
PubMed search

6664

20666

ENSG00000176887

ENSMUSG00000063632

P35716

Q7M6Y2

NM_003108

NM_009234

NP_003099

NP_033260

Transcription factor SOX-11 is a protein that in humans is encoded by the SOX11 gene.

This intronless gene encodes a member of the group C SOX (SRY-related HMG-box) transcription factor family involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may function in the developing nervous system and play a role in tumorigenesis and adult neurogenesis. Tuj1 and Tead2 are suggested as direct target of Sox11.

Mutations in SOX11 are associated to Coffin-Siris syndrome .

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