SOS1

SOS1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1AWE, 1BKD, 1DBH, 1NVU, 1NVV, 1NVW, 1NVX, 1Q9C, 1XD2, 1XD4, 1XDV, 3KSY, 4NYI, 4NYJ, 4NYM, 4URU, 4URV, 4URW, 4URX, 4URY, 4URZ, 4US0, 4US1, 4US2, 2II0
Identifiers
Aliases	SOS1, GF1, GGF1, GINGF, HGF, NS4, SOS Ras/Rac guanine nucleotide exchange factor 1
External IDs	OMIM: 182530 MGI: 98354 HomoloGene: 4117 GeneCards: SOS1
Gene ontology Molecular function • DNA binding • GTPase activator activity • SH3 domain binding • protein binding • protein heterodimerization activity • Ras guanyl-nucleotide exchange factor activity • Rho guanyl-nucleotide exchange factor activity • guanyl-nucleotide exchange factor activity Cellular component • cytosol • postsynaptic density • plasma membrane • neuronal cell body Biological process • regulation of pro-B cell differentiation • hair follicle development • insulin receptor signaling pathway • palate development • heart trabecula morphogenesis • regulation of T cell proliferation • positive regulation of small GTPase mediated signal transduction • blood vessel morphogenesis • epidermal growth factor receptor signaling pathway • vitellogenesis • multicellular organism growth • lymphocyte homeostasis • heart morphogenesis • B cell homeostasis • eyelid development in camera-type eye • MAPK cascade • axon guidance • Fc-epsilon receptor signaling pathway • regulation of T cell differentiation in thymus • pericardium morphogenesis • positive regulation of apoptotic process • midbrain morphogenesis • cardiac atrium morphogenesis • Ras protein signal transduction • regulation of Rho protein signal transduction • regulation of small GTPase mediated signal transduction • positive regulation of epidermal growth factor receptor signaling pathway • leukocyte migration • signal transduction • positive regulation of GTPase activity • small GTPase mediated signal transduction • ERBB2 signaling pathway • neurotrophin TRK receptor signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6654	20662
Ensembl	ENSG00000115904	ENSMUSG00000024241
UniProt	Q07889	Q62245
RefSeq (mRNA)	NM_005633	NM_009231
RefSeq (protein)	NP_005624	NP_033257.2 NP_033257
Location (UCSC)	Chr 2: 38.98 – 39.12 Mb	Chr 17: 80.39 – 80.48 Mb
PubMed search

1AWE, 1BKD, 1DBH, 1NVU, 1NVV, 1NVW, 1NVX, 1Q9C, 1XD2, 1XD4, 1XDV, 3KSY, 4NYI, 4NYJ, 4NYM, 4URU, 4URV, 4URW, 4URX, 4URY, 4URZ, 4US0, 4US1, 4US2, 2II0

6654

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