SOD1

SOD1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1AZV, 1BA9, 1DSW, 1FUN, 1HL4, 1HL5, 1KMG, 1L3N, 1MFM, 1N18, 1N19, 1OEZ, 1OZT, 1OZU, 1P1V, 1PTZ, 1PU0, 1RK7, 1SOS, 1SPD, 1UXL, 1UXM, 2AF2, 2C9S, 2C9U, 2C9V, 2GBT, 2GBU, 2GBV, 2LU5, 2MP3, 2NNX, 2R27, 2V0A, 2VR6, 2VR7, 2VR8, 2WKO, 2WYT, 2WYZ, 2WZ0, 2WZ5, 2WZ6, 2XJK, 2XJL, 2ZKW, 2ZKX, 2ZKY, 3CQP, 3CQQ, 3ECU, 3ECV, 3ECW, 3GQF, 3GTV, 3GZO, 3GZP, 3GZQ, 3H2P, 3H2Q, 3HFF, 3K91, 3KH3, 3KH4, 3LTV, 3QQD, 3RE0, 3T5W, 4A7G, 4A7Q, 4A7S, 4A7T, 4A7U, 4A7V, 4B3E, 4BCY, 4BCZ, 4BD4, 4FF9, 4MCM, 4MCN, 4NIN, 4NIP, 4OH2, 4XCR
Identifiers
Aliases	SOD1, ALS, ALS1, HEL-S-44, IPOA, SOD, hSod1, homodimer, superoxide dismutase 1, soluble
External IDs	OMIM: 147450 MGI: 98351 HomoloGene: 392 GeneCards: SOD1
Gene ontology Molecular function • metal ion binding • enzyme binding • oxidoreductase activity • superoxide dismutase activity • Rac GTPase binding • protein homodimerization activity • zinc ion binding • protein binding • copper ion binding • protein phosphatase 2B binding • chaperone binding • antioxidant activity • identical protein binding Cellular component • cytoplasm • cytosol • mitochondrial intermembrane space • extracellular region • mitochondrion • neuron projection • dendrite cytoplasm • dense core granule • nucleus • myelin sheath • peroxisome • lysosome • extracellular exosome • extracellular matrix • plasma membrane • secretory granule • nucleoplasm • protein complex • neuronal cell body • mitochondrial matrix • cytoplasmic vesicle • axon cytoplasm • extracellular space Biological process • negative regulation of neuron apoptotic process • muscle cell cellular homeostasis • response to copper ion • placenta development • response to amphetamine • positive regulation of catalytic activity • response to heat • response to organic substance • anterograde axonal transport • cell aging • spermatogenesis • response to ethanol • neurofilament cytoskeleton organization • heart contraction • embryo implantation • locomotory behavior • response to reactive oxygen species • thymus development • removal of superoxide radicals • regulation of GTPase activity • transmission of nerve impulse • response to antibiotic • myeloid cell homeostasis • response to oxidative stress • reactive oxygen species metabolic process • regulation of T cell differentiation in thymus • retina homeostasis • response to nutrient levels • hydrogen peroxide biosynthetic process • regulation of protein kinase activity • negative regulation of cholesterol biosynthetic process • cellular response to potassium ion • retrograde axonal transport • glutathione metabolic process • response to antipsychotic drug • negative regulation of apoptotic process • cellular response to cadmium ion • response to carbon monoxide • regulation of blood pressure • activation of MAPK activity • response to axon injury • relaxation of vascular smooth muscle • ovarian follicle development • cellular response to ATP • response to hydrogen peroxide • superoxide metabolic process • peripheral nervous system myelin maintenance • response to superoxide • positive regulation of cytokine production • regulation of multicellular organism growth • aging • platelet degranulation • sensory perception of sound • superoxide anion generation • auditory receptor cell stereocilium organization • regulation of mitochondrial membrane potential • positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway • positive regulation of apoptotic process • cellular response to oxidative stress • positive regulation of superoxide anion generation • regulation of organ growth • oxidation-reduction process • response to drug • cellular iron ion homeostasis Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6647	20655
Ensembl	ENSG00000142168	ENSMUSG00000022982
UniProt	P00441	P08228
RefSeq (mRNA)	NM_000454	NM_011434
RefSeq (protein)	NP_000445	NP_035564.1 NP_035564
Location (UCSC)	Chr 21: 31.66 – 31.67 Mb	Chr 16: 90.22 – 90.23 Mb
PubMed search

1AZV, 1BA9, 1DSW, 1FUN, 1HL4, 1HL5, 1KMG, 1L3N, 1MFM, 1N18, 1N19, 1OEZ, 1OZT, 1OZU, 1P1V, 1PTZ, 1PU0, 1RK7, 1SOS, 1SPD, 1UXL, 1UXM, 2AF2, 2C9S, 2C9U, 2C9V, 2GBT, 2GBU, 2GBV, 2LU5, 2MP3, 2NNX, 2R27, 2V0A, 2VR6, 2VR7, 2VR8, 2WKO, 2WYT, 2WYZ, 2WZ0, 2WZ5, 2WZ6, 2XJK, 2XJL, 2ZKW, 2ZKX, 2ZKY, 3CQP, 3CQQ, 3ECU, 3ECV, 3ECW, 3GQF, 3GTV, 3GZO, 3GZP, 3GZQ, 3H2P, 3H2Q, 3HFF, 3K91, 3KH3, 3KH4, 3LTV, 3QQD, 3RE0, 3T5W, 4A7G, 4A7Q, 4A7S, 4A7T, 4A7U, 4A7V, 4B3E, 4BCY, 4BCZ, 4BD4, 4FF9, 4MCM, 4MCN, 4NIN, 4NIP, 4OH2, 4XCR

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