SOAT2

SOAT2
Identifiers
Aliases	SOAT2, ACACT2, ACAT2, ARGP2, sterol O-acyltransferase 2
External IDs	MGI: 1332226 HomoloGene: 68355 GeneCards: SOAT2
Gene ontology Molecular function • transferase activity • cholesterol binding • O-acyltransferase activity • fatty-acyl-CoA binding • sterol O-acyltransferase activity • transferase activity, transferring acyl groups • cholesterol O-acyltransferase activity Cellular component • membrane • integral component of membrane • brush border • endoplasmic reticulum • endoplasmic reticulum membrane Biological process • very-low-density lipoprotein particle assembly • steroid metabolic process • macrophage derived foam cell differentiation • intestinal cholesterol absorption • cholesterol efflux • lipid metabolic process • cholesterol esterification • cholesterol homeostasis • cholesterol metabolic process • low-density lipoprotein particle clearance Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8435	223920
Ensembl	ENSG00000167780	ENSMUSG00000023045
UniProt	O75908	O88908
RefSeq (mRNA)	NM_003578	NM_146064
RefSeq (protein)	NP_003569	NP_666176
Location (UCSC)	Chr 12: 53.1 – 53.12 Mb	Chr 15: 102.15 – 102.16 Mb
PubMed search

8435

223920

ENSG00000167780

ENSMUSG00000023045

O75908

O88908

NM_003578

NM_146064

NP_003569

NP_666176

Sterol O-acyltransferase 2, also known as SOAT2, is an enzyme that in humans is encoded by the SOAT2 gene.

This gene is a member of a small family of Acyl-CoA:cholesterol acyltransferases. The gene encodes a membrane-bound enzyme localized in the endoplasmic reticulum that produces intracellular cholesterol esters from long-chain fatty acyl CoA and cholesterol. The cholesterol esters are then stored as cytoplasmic lipid droplets inside the cell. The enzyme is implicated in cholesterol absorption in the intestine and in the assembly and secretion of apolipoprotein B-containing lipoproteins such as very-low-density lipoprotein (VLDL). Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.

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