SNX9

SNX9
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2RAI, 2RAJ, 2RAK, 3DYT, 3DYU, 3LGE
Identifiers
Aliases	SNX9, SDP1, SH3PX1, SH3PXD3A, WISP, sorting nexin 9
External IDs	MGI: 1913866 HomoloGene: 49454 GeneCards: SNX9
Gene ontology Molecular function • protein homodimerization activity • Arp2/3 complex binding • 1-phosphatidylinositol binding • protein binding • phosphatidylinositol binding • ubiquitin protein ligase binding • lipid binding • cadherin binding Cellular component • cytoplasm • Golgi apparatus • cell projection • membrane • ruffle • extrinsic component of cytoplasmic side of plasma membrane • plasma membrane • trans-Golgi network • extracellular exosome • cytoplasmic vesicle membrane • clathrin-coated vesicle • cytosol • cytoplasmic vesicle Biological process • endocytosis • cleavage furrow formation • mitotic cytokinesis • positive regulation of membrane protein ectodomain proteolysis • receptor-mediated endocytosis • plasma membrane tubulation • cell division • endosomal transport • positive regulation of GTPase activity • transport • positive regulation of protein oligomerization • protein transport • lipid tube assembly • cell cycle • intracellular protein transport • positive regulation of protein kinase activity • membrane organization Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51429	66616
Ensembl	ENSG00000130340	ENSMUSG00000002365
UniProt	Q9Y5X1	Q91VH2
RefSeq (mRNA)	NM_016224	NM_025664
RefSeq (protein)	NP_057308	NP_079940.2 NP_079940
Location (UCSC)	Chr 6: 157.7 – 157.95 Mb	Chr 17: 5.84 – 5.93 Mb
PubMed search

2RAI, 2RAJ, 2RAK, 3DYT, 3DYU, 3LGE

51429

66616

ENSG00000130340

ENSMUSG00000002365

Q9Y5X1

Q91VH2

NM_016224

NM_025664

NP_057308

NP_079940.2
NP_079940

Sorting nexin-9 is a protein that in humans is encoded by the SNX9 gene.

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but does contain an SH3 domain near its N-terminus. This protein interacts with the cytoplasmic domains of the precursor but not the processed forms of a disintegrin and metalloprotease domain 9 and 15. This protein binds the beta-appendage domain of adaptor protein 2 and may function to assist adaptor protein 2 in its role at the plasma membrane. This protein interacts with activated Cdc42-associated kinase-2 to regulate the degradation of epidermal growth factor receptor protein.

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Wikipedia