SMC3

SMC3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2WD5
Identifiers
Aliases	SMC3, BAM, BMH, CDLS3, CSPG6, HCAP, SMC3L1, structural maintenance of chromosomes 3
External IDs	MGI: 1339795 HomoloGene: 3974 GeneCards: SMC3
Gene ontology Molecular function • microtubule motor activity • nucleotide binding • mediator complex binding • chromatin binding • protein binding • protein heterodimerization activity • ATP binding • dynein complex binding • protein complex binding • beta-tubulin binding Cellular component • cytosol • meiotic cohesin complex • nuclear meiotic cohesin complex • nuclear matrix • chromosome • nucleoplasm • lateral element • chromatin • chromosome, centromeric region • nucleus • basement membrane • intracellular • cohesin complex • mitotic spindle pole Biological process • regulation of DNA replication • chromosome organization • cellular response to DNA damage stimulus • stem cell population maintenance • cell division • negative regulation of DNA endoreduplication • mitotic sister chromatid cohesion • cell cycle • DNA repair • sister chromatid cohesion • mitotic cell cycle • positive regulation by host of viral release from host cell • meiotic cell cycle • interaction with symbiont • regulation of mitotic spindle assembly Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9126	13006
Ensembl	ENSG00000108055	ENSMUSG00000024974
UniProt	Q9UQE7	Q9CW03
RefSeq (mRNA)	NM_005445	NM_007790
RefSeq (protein)	NP_005436	NP_031816
Location (UCSC)	Chr 10: 110.57 – 110.6 Mb	Chr 19: 53.6 – 53.65 Mb
PubMed search

2WD5

9126

13006

ENSG00000108055

ENSMUSG00000024974

Q9UQE7

Q9CW03

NM_005445

NM_007790

NP_005436

NP_031816

Structural maintenance of chromosomes protein 3 (SMC-3) is a nuclear protein that in humans is encoded by the SMC3 gene. A post-translated modified form that is excreted is known as basement membrane-associated chondroitin proteoglycan (bamacan).

This gene belongs to the SMC3 subfamily of SMC proteins. The encoded protein occurs in certain cell types as either an intracellular, nuclear protein or a secreted protein. The nuclear form, known as structural maintenance of chromosomes 3, is a component of the multimeric cohesin complex that holds together sister chromatids during mitosis, enabling proper chromosome segregation. Post-translational modification of the encoded protein by the addition of chondroitin sulfate chains gives rise to the secreted proteoglycan bamacan, an abundant basement membrane protein.

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Wikipedia