SLIT2

SLIT2

Protein SLIT2 PDB 2V70.png

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2V70, 2V9S, 2V9T, 2WFH

Identifiers

SLIT2, SLIL3, Slit-2, slit guidance ligand 2

External IDs

MGI: 1315205 HomoloGene: 3516 GeneCards: SLIT2

Gene ontology
Molecular function	• calcium ion binding • heparin binding • protein homodimerization activity • GTPase inhibitor activity • laminin-1 binding • protein binding • identical protein binding • Roundabout binding • proteoglycan binding
Cellular component	• cytoplasm • membrane • extracellular region • cell surface • extracellular exosome • plasma membrane • extracellular space
Biological process	• negative regulation of protein phosphorylation • negative regulation of chemokine-mediated signaling pathway • negative regulation of neutrophil chemotaxis • negative regulation of cellular response to growth factor stimulus • chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration • cell differentiation • ureteric bud development • negative chemotaxis • negative regulation of actin filament polymerization • negative regulation of small GTPase mediated signal transduction • negative regulation of retinal ganglion cell axon guidance • negative regulation of mononuclear cell migration • corticospinal neuron axon guidance through spinal cord • negative regulation of smooth muscle cell migration • Roundabout signaling pathway • positive regulation of axonogenesis • nervous system development • cell migration involved in sprouting angiogenesis • negative regulation of endothelial cell migration • axon guidance • multicellular organism development • chemotaxis • negative regulation of smooth muscle cell chemotaxis • cellular response to hormone stimulus • negative regulation of cell migration • negative regulation of monocyte chemotaxis • negative regulation of cell growth • response to cortisol • apoptotic process involved in luteolysis • positive regulation of apoptotic process • induction of negative chemotaxis • cellular response to heparin • motor neuron axon guidance • branching morphogenesis of an epithelial tube • negative regulation of leukocyte chemotaxis • chemorepulsion involved in postnatal olfactory bulb interneuron migration • axon extension involved in axon guidance • negative regulation of lamellipodium assembly • negative regulation of vascular permeability • retinal ganglion cell axon guidance • negative regulation of GTPase activity
Sources:Amigo / QuickGO

RNA expression pattern

PBB GE SLIT2 209897 s at fs.png

More reference expression data

Orthologs

Species

Human

Mouse


9353


20563


ENSG00000145147


ENSMUSG00000031558


O94813


Q9R1B9

RefSeq (mRNA)


NM_001289135 NM_001289136 NM_004787


NM_001291227 NM_001291228 NM_178804

RefSeq (protein)


NP_001276064 NP_001276065 NP_004778


NP_001278156 NP_001278157 NP_848919

Location (UCSC)

Chr 4: 20.25 – 20.62 Mb

Chr 5: 47.98 – 48.31 Mb

PubMed search

2V70, 2V9S, 2V9T, 2WFH

ENSG00000145147

ENSMUSG00000031558

NM_001289135
NM_001289136
NM_004787

NM_001291227
NM_001291228
NM_178804

NP_001276064
NP_001276065
NP_004778

NP_001278156
NP_001278157
NP_848919

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Wikipedia

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