SLC30A8

SLC30A8
Identifiers
Aliases	SLC30A8, ZNT8, ZnT-8, solute carrier family 30 member 8
External IDs	OMIM: 611145 MGI: 2442682 HomoloGene: 13795 GeneCards: SLC30A8
Gene ontology Molecular function • protein homodimerization activity • cation transmembrane transporter activity • zinc ion binding • protein binding • zinc ion transmembrane transporter activity Cellular component • integral component of membrane • Golgi apparatus • secretory granule membrane • membrane • plasma membrane • transport vesicle membrane • secretory granule • cytoplasmic vesicle • cell Biological process • response to interleukin-1 • response to interferon-gamma • glucose homeostasis • regulation of vesicle-mediated transport • zinc II ion transport • response to zinc ion • cation transport • insulin secretion • ion transport • response to glucose • cation transmembrane transport • sequestering of zinc ion • cellular zinc ion homeostasis • Q22291617 • regulation of sequestering of zinc ion • positive regulation of insulin secretion • zinc II ion transmembrane transport • transmembrane transport Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	169026	239436
Ensembl	ENSG00000164756	ENSMUSG00000022315
UniProt	Q8IWU4	Q8BGG0
RefSeq (mRNA)	NM_001172811 NM_001172813 NM_001172814 NM_001172815 NM_173851	NM_172816
RefSeq (protein)	NP_001166282 NP_001166284 NP_001166285 NP_001166286 NP_776250	NP_766404
Location (UCSC)	Chr 8: 116.95 – 117.18 Mb	Chr 15: 52.3 – 52.34 Mb
PubMed search

169026

239436

ENSG00000164756

ENSMUSG00000022315

Q8IWU4

Q8BGG0

NM_001172811
NM_001172813
NM_001172814
NM_001172815
NM_173851

NM_172816

NP_001166282
NP_001166284
NP_001166285
NP_001166286
NP_776250

NP_766404

Solute carrier family 30 (zinc transporter), member 8, also known as SLC30A8, is a human gene that codes for a zinc transporter related to insulin secretion in humans. Certain alleles of this gene may increase the risk for developing type 2 diabetes, but a loss-of-function mutation appears to greatly reduce the risk of diabetes.

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Wikipedia