SLC30A3

Identifiers

SLC30A3, ZNT3, solute carrier family 30 member 3

External IDs

Gene ontology
Molecular function	• zinc-transporting ATPase activity • protein binding • cation transmembrane transporter activity
Cellular component	• synapse • integral component of plasma membrane • late endosome membrane • lysosomal membrane • synaptic vesicle membrane • cytoplasm • endosome • cell junction • lysosome • integral component of membrane • late endosome • membrane • cytoplasmic vesicle • neuron projection • synaptic vesicle
Biological process	• response to zinc ion • ion transport • positive regulation of transport • cation transport • regulation of sequestering of zinc ion • cation transmembrane transport • zinc II ion transport • zinc II ion transmembrane transport • transmembrane transport • transport
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


7781


22784


ENSG00000115194


ENSMUSG00000029151


Q99726


P97441

RefSeq (mRNA)


NM_003459 NM_001318949 NM_001318950 NM_001318951


NM_011773 NM_001347323

RefSeq (protein)


NP_001305878 NP_001305879 NP_001305880 NP_003450


NP_001334252 NP_035903

Location (UCSC)

PubMed search

Zinc transporter 3 also known as solute carrier family 30 member 3 is a protein in humans that is encoded by the SLC30A3 gene.

The SLC30A3 gene codes for the ZnT-3 SLC30A family membrane transport protein. ZnT-3 is required for the accumulation of zinc ions inside synaptic vesicles. In mice, ZnT-3 is required for some forms of memory that depend on the hippocampus and the amygdala. Zinc transport by ZnT-3 modulates memory formation by acting through the extracellular signal-regulated kinases signaling pathway.Angiotensin II-induced senescence of vascular smooth muscle cells requires down-regulation of ZnT-3 and ZnT-10.