SLC26A2

SLC26A2
Identifiers
Aliases	SLC26A2, D5S1708, DTD, DTDST, EDM4, MST153, MSTP157, solute carrier family 26 member 2
External IDs	OMIM: 606718 MGI: 892977 HomoloGene: 73876 GeneCards: SLC26A2
Gene ontology Molecular function • anion:anion antiporter activity • secondary active sulfate transmembrane transporter activity • bicarbonate transmembrane transporter activity • oxalate transmembrane transporter activity • chloride channel activity • sulfate transmembrane transporter activity Cellular component • integral component of membrane • membrane • extracellular exosome • integral component of plasma membrane • plasma membrane Biological process • ossification • regulation of membrane potential • regulation of intracellular pH • chloride transmembrane transport • ion transport • bicarbonate transport • 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process • transport • oxalate transport • transmembrane transport • sulfate transport • sulfate transmembrane transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	1836	13521
Ensembl	ENSG00000155850	ENSMUSG00000034320
UniProt	P50443	Q62273
RefSeq (mRNA)	NM_000112	NM_007885
RefSeq (protein)	NP_000103	NP_031911.1 NP_031911
Location (UCSC)	Chr 5: 149.96 – 149.99 Mb	Chr 18: 61.19 – 61.21 Mb
PubMed search

1836

13521

ENSG00000155850

ENSMUSG00000034320

P50443

Q62273

NM_000112

NM_007885

NP_000103

NP_031911.1
NP_031911

The SLC26A2 protein is a member of the solute carrier family. In humans, this transporter is encoded by the SLC26A2 gene.

The diastrophic dysplasia sulfate transporter is a transmembrane glycoprotein implicated in the pathogenesis of several human chondrodysplasias. It apparently is critical in cartilage for sulfation of proteoglycans and extracellular matrix organization.

Deficiencies are associated with many forms of osteochondrodysplasia. These include:

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