SLC22A4

SLC22A4
Identifiers
Aliases	SLC22A4, OCTN1, solute carrier family 22 member 4, DFNB60
External IDs	MGI: 1353479 HomoloGene: 81701 GeneCards: SLC22A4
Gene ontology Molecular function • nucleotide binding • PDZ domain binding • transmembrane transporter activity • transporter activity • cation:cation antiporter activity • protein binding • carnitine transmembrane transporter activity • secondary active organic cation transmembrane transporter activity • quaternary ammonium group transmembrane transporter activity • ATP binding • symporter activity • organic anion transmembrane transporter activity Cellular component • integral component of membrane • membrane • plasma membrane • integral component of plasma membrane • apical plasma membrane • mitochondrion Biological process • body fluid secretion • sodium ion transport • quaternary ammonium group transport • ion transport • organic cation transport • transport • carnitine transport • triglyceride metabolic process • carnitine metabolic process • cation transmembrane transport • ion transmembrane transport • carnitine transmembrane transport • transmembrane transport • organic anion transport Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6583	30805
Ensembl	ENSG00000197208	ENSMUSG00000020334
UniProt	Q9H015	Q9Z306
RefSeq (mRNA)	NM_003059	NM_019687 NM_001330304
RefSeq (protein)	NP_003050	NP_001317233 NP_062661
Location (UCSC)	Chr 5: 132.29 – 132.34 Mb	Chr 11: 53.98 – 54.03 Mb
PubMed search

6583

30805

ENSG00000197208

ENSMUSG00000020334

Q9H015

Q9Z306

NM_003059

NM_019687
NM_001330304

NP_003050

NP_001317233
NP_062661

Solute carrier family 22, member 4, also known as SLC22A4, is a human gene; the encoded protein is known as the ergothioneine transporter.

The encoded protein is an integral protein of the plasma membrane containing 12 transmembrane segments. The first functional designation of this protein was OCTN1 ("organic cation transporter, novel, type 1"), but efficiency of transport for organic cations (e.g., tetraethylammonium) is very low. The transport efficiency for carnitine is also negligible. Instead, the protein is responsible for the cotransport of sodium ions and ergothioneine, which is an antioxidant, into cells. Thus, a more appropriate functional designation is ETT ("ergothioneine transporter").

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