SLC1A1

SLC1A1
Identifiers
Aliases	SLC1A1, EAAC1, EAAT3, SCZD18, DCBXA, solute carrier family 1 member 1
External IDs	MGI: 105083 HomoloGene: 20881 GeneCards: SLC1A1
Gene ontology Molecular function • cysteine transmembrane transporter activity • protein binding • symporter activity • L-glutamate transmembrane transporter activity • glutamate binding • amino acid transmembrane transporter activity • high-affinity glutamate transmembrane transporter activity • chloride transmembrane transporter activity • glutamate:sodium symporter activity Cellular component • integral component of membrane • membrane • plasma membrane • apical plasma membrane • extracellular exosome • integral component of plasma membrane Biological process • chemical synaptic transmission • D-aspartate import • ion transport • positive regulation of heart rate • glutamate secretion • L-glutamate transmembrane transport • transport • cysteine transport • protein homooligomerization • L-glutamate import • L-glutamate transport • cysteine transmembrane transport • L-aspartate import across plasma membrane • D-aspartate import across plasma membrane • chloride transmembrane transport • L-glutamate import across plasma membrane Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6505	20510
Ensembl	ENSG00000106688	ENSMUSG00000024935
UniProt	P43005	P51906
RefSeq (mRNA)	NM_004170	NM_009199
RefSeq (protein)	NP_004161	NP_033225.1 NP_033225
Location (UCSC)	Chr 9: 4.49 – 4.59 Mb	Chr 19: 28.84 – 28.91 Mb
PubMed search

6505

20510

ENSG00000106688

ENSMUSG00000024935

P43005

P51906

NM_004170

NM_009199

NP_004161

NP_033225.1
NP_033225

SLC1A1, also known as excitatory amino-acid transporter 3 (EAAT3), is a protein that in humans is encoded by the SLC1A1 gene.

Excitatory amino-acid transporter 3 is a member of the high-affinity glutamate transporters which plays an essential role in transporting glutamate across plasma membranes in neurons. In the brain, excitatory amino acid transporters are crucial in terminating the postsynaptic action of the neurotransmitter glutamate, and in maintaining extracellular glutamate concentrations below neurotoxic levels. EAAT3 also transports aspartate, and mutations in this gene are thought to cause dicarboxylic aminoaciduria, also known as glutamate-aspartate transport defect. EAAT3 is also the major route of neuronal cysteine uptake. Cysteine is a component of the major antioxidant glutathione, and mice lacking EAAT3 exhibit reduced levels of glutathione in neurons, increased oxidative stress, and age-dependent loss of neurons, especially neurons of the substania nigra.

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Wikipedia