SKI protein

SKI
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1MR1, 1SBX
Identifiers
Aliases	SKI, SKI proto-oncogene, SGS, SKV
External IDs	MGI: 98310 HomoloGene: 31124 GeneCards: SKI
Gene ontology Molecular function • transcription corepressor activity • protein domain specific binding • histone deacetylase inhibitor activity • zinc ion binding • protein binding • SMAD binding • repressing transcription factor binding • protein kinase binding • ubiquitin protein ligase binding Cellular component • PML body • centrosome • nuclear body • protein complex • nucleus • nucleoplasm • transcription factor complex • cytoplasm • transcriptional repressor complex Biological process • palate development • myotube differentiation • SMAD protein signal transduction • somatic stem cell population maintenance • nose morphogenesis • cell motility • bone morphogenesis • negative regulation of transcription from RNA polymerase II promoter • negative regulation of transforming growth factor beta receptor signaling pathway • BMP signaling pathway • negative regulation of osteoblast differentiation • myelination in peripheral nervous system • protein homotrimerization • negative regulation of BMP signaling pathway • positive regulation of Wnt signaling pathway • negative regulation of activin receptor signaling pathway • neural tube closure • lens morphogenesis in camera-type eye • embryonic limb morphogenesis • skeletal muscle fiber development • retina development in camera-type eye • camera-type eye development • positive regulation of DNA binding • olfactory bulb development • cell proliferation • anterior/posterior axis specification • negative regulation of fibroblast proliferation • face morphogenesis • camera-type eye morphogenesis • negative regulation of Schwann cell proliferation • negative regulation of cell proliferation • positive regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • negative regulation of histone deacetylation • neuron development • transforming growth factor beta receptor signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6497	20481
Ensembl	ENSG00000157933	ENSMUSG00000029050
UniProt	P12755	Q60698
RefSeq (mRNA)	NM_003036	NM_011385
RefSeq (protein)	NP_003027	n/a
Location (UCSC)	Chr 1: 2.23 – 2.31 Mb	Chr 4: 155.15 – 155.22 Mb
PubMed search

1MR1, 1SBX

6497

20481

ENSG00000157933

ENSMUSG00000029050

P12755

Q60698

NM_003036

NM_011385

NP_003027

n/a

The SKI protein is a nuclear proto-oncogene that is associated with tumors at high cellular concentrations. SKI has been shown to interfere with normal cellular functioning by both directly impeding expression of certain genes inside the nucleus of the cell as well as disrupting signaling proteins that activate genes.

SKI negatively regulates transforming growth factor-beta (TGF-beta) by directly interacting with Smads and repressing the transcription of TGF-beta responsive genes. This has been associated with cancer due to the large number of roles that peptide growth factors, of which TGF-beta are a subfamily, play in regulating cellular functions such as cell proliferation, apoptosis, specification, and developmental fate.

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