SIX1

SIX1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4EGC
Identifiers
Aliases	SIX1, BOS3, DFNA23, TIP39, SIX homeobox 1
External IDs	MGI: 102780 HomoloGene: 4360 GeneCards: SIX1
Gene ontology Molecular function • DNA binding • sequence-specific DNA binding • transcription factor activity, sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • chromatin binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • protein binding • transcription regulatory region DNA binding • transcription coactivator binding Cellular component • cytoplasm • transcription factor complex • nucleolus • nucleus Biological process • pattern specification process • negative regulation of neuron apoptotic process • regulation of neuron differentiation • embryonic skeletal system morphogenesis • mesonephric tubule formation • neurogenesis • animal organ development • ureteric bud development • myoblast migration • positive regulation of branching involved in ureteric bud morphogenesis • renal system development • regulation of transcription, DNA-templated • epithelial cell differentiation • olfactory placode formation • regulation of skeletal muscle cell differentiation • tongue development • organ induction • kidney development • anatomical structure development • thymus development • ureter smooth muscle cell differentiation • neuron fate specification • myotome development • skeletal system morphogenesis • outflow tract morphogenesis • trigeminal ganglion development • negative regulation of apoptotic process • negative regulation of transcription from RNA polymerase II promoter • sensory perception of sound • aorta morphogenesis • regulation of branch elongation involved in ureteric bud branching • fungiform papilla morphogenesis • GO:0006350 transcription, DNA-templated • generation of neurons • otic vesicle development • regulation of protein localization • positive regulation of transcription, DNA-templated • multicellular organism development • branching involved in ureteric bud morphogenesis • thyroid gland development • inner ear morphogenesis • cochlea morphogenesis • positive regulation of ureteric bud formation • positive regulation of mesenchymal cell proliferation involved in ureter development • middle ear morphogenesis • regulation of synaptic growth at neuromuscular junction • protein localization to nucleus • regulation of gene expression • embryonic cranial skeleton morphogenesis • inner ear development • positive regulation of secondary heart field cardioblast proliferation • negative regulation of branching involved in ureteric bud morphogenesis • cell proliferation • regulation of epithelial cell proliferation • regulation of skeletal muscle satellite cell proliferation • skeletal muscle tissue development • metanephric mesenchyme development • facial nerve morphogenesis • positive regulation of transcription from RNA polymerase II promoter • pharyngeal system development • apoptotic process • transcription from RNA polymerase II promoter • cellular response to 3,3',5-triiodo-L-thyronine Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6495	20471
Ensembl	ENSG00000126778	ENSMUSG00000051367
UniProt	Q15475	Q62231
RefSeq (mRNA)	NM_005982	NM_009189
RefSeq (protein)	NP_005973	NP_033215.2 NP_033215
Location (UCSC)	Chr 14: 60.64 – 60.66 Mb	Chr 12: 73.04 – 73.05 Mb
PubMed search

4EGC

6495

20471

ENSG00000126778

ENSMUSG00000051367

Q15475

Q62231

NM_005982

NM_009189

NP_005973

NP_033215.2
NP_033215

Homeobox protein SIX1 (Sineoculis homeobox homolog 1) is a protein that in humans is encoded by the SIX1 gene.

The vertebrate SIX genes are homologs of the Drosophila 'sine oculis' (so) gene, which is expressed primarily in the developing visual system of the fly. Members of the SIX gene family encode proteins that are characterized by a divergent DNA-binding homeodomain and an upstream SIX domain, which may be involved both in determining DNA-binding specificity and in mediating protein–protein interactions. Genes in the SIX family have been shown to play roles in vertebrate and insect development or have been implicated in maintenance of the differentiated state of tissues.[supplied by OMIM]

SIX1 has been shown to interact with EYA1, DACH, GRO and MDFI.

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Wikipedia