SIRT3

SIRT3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3GLR, 3GLS, 3GLU, 4BN4, 4BN5, 4BV3, 4BVB, 4BVE, 4BVF, 4BVG, 4BVH, 4C78, 4C7B, 4FVT, 4FZ3, 4HD8, 4JSR, 4JT8, 4JT9, 4O8Z, 4V1C, 5D7N, 5BWN, 5BWO
Identifiers
Aliases	SIRT3, SIR2L3, sirtuin 3
External IDs	MGI: 1927665 HomoloGene: 81827 GeneCards: SIRT3
Gene ontology Molecular function • NAD+ ADP-ribosyltransferase activity • protein binding • hydrolase activity • NAD+ binding • metal ion binding • enzyme binding • zinc ion binding • NAD-dependent histone deacetylase activity • NAD-dependent protein deacetylase activity Cellular component • mitochondrion • mitochondrial matrix Biological process • protein deacetylation • aerobic respiration • mitochondrion organization • peptidyl-lysine deacetylation • protein ADP-ribosylation • negative regulation of ERK1 and ERK2 cascade • positive regulation of insulin secretion • negative regulation of reactive oxygen species metabolic process • aging • histone deacetylation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23410	64384
Ensembl	ENSG00000142082	ENSMUSG00000025486
UniProt	Q9NTG7	Q8R104
RefSeq (mRNA)	NM_001017524 NM_012239	NM_001127351 NM_001177804 NM_022433
RefSeq (protein)	NP_001017524 NP_036371	NP_001120823.1 NP_001171275.1 NP_071878.2 NP_001120823 NP_001171275 NP_071878
Location (UCSC)	Chr 11: 0.22 – 0.24 Mb	Chr 7: 140.86 – 140.88 Mb
PubMed search

3GLR, 3GLS, 3GLU, 4BN4, 4BN5, 4BV3, 4BVB, 4BVE, 4BVF, 4BVG, 4BVH, 4C78, 4C7B, 4FVT, 4FZ3, 4HD8, 4JSR, 4JT8, 4JT9, 4O8Z, 4V1C, 5D7N, 5BWN, 5BWO

23410

64384

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Wikipedia