SIR2

SIRT1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
4I5I, 4IF6, 4IG9, 4KXQ, 4ZZH, 4ZZI, 4ZZJ, 5BTR

Identifiers

Aliases

SIRT1, SIR2L1, SIR2, hSIR2, SIR2alpha, Sirtuin 1

External IDs

MGI: 2135607 HomoloGene: 56556 GeneCards: SIRT1

Targeted by Drug

SRT1720

Gene ontology
Molecular function	• transcription corepressor activity • protein domain specific binding • core promoter sequence-specific DNA binding • protein C-terminus binding • keratin filament binding • transcription factor binding • metal ion binding • HLH domain binding • enzyme binding • protein deacetylase activity • histone binding • protein binding • NAD-dependent histone deacetylase activity • NAD-dependent protein deacetylase activity • histone deacetylase activity • p53 binding • nuclear hormone receptor binding • mitogen-activated protein kinase binding • deacetylase activity • bHLH transcription factor binding • NAD+ binding • identical protein binding • NAD+ ADP-ribosyltransferase activity • hydrolase activity • NAD-dependent histone deacetylase activity (H3-K9 specific) • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • protein kinase B binding
Cellular component	• cytoplasm • nuclear envelope • rDNA heterochromatin • chromatin silencing complex • mitochondrion • nucleus • ESC/E(Z) complex • nucleolus • nuclear chromatin • chromatin • nucleoplasm • nuclear euchromatin • PML body • nuclear heterochromatin • nuclear inner membrane • cytosol • axon • growth cone
Biological process	• cellular triglyceride homeostasis • positive regulation of MHC class II biosynthetic process • DNA synthesis involved in DNA repair • positive regulation of protein phosphorylation • positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway • rhythmic process • single strand break repair • muscle organ development • histone H3-K9 deacetylation • negative regulation of cellular response to testosterone stimulus • regulation of peroxisome proliferator activated receptor signaling pathway • cellular response to DNA damage stimulus • regulation of bile acid biosynthetic process • DNA replication • negative regulation of TOR signaling • positive regulation of cysteine-type endopeptidase activity involved in apoptotic process • regulation of glucose metabolic process • chromatin silencing at rDNA • negative regulation of DNA damage response, signal transduction by p53 class mediator • methylation-dependent chromatin silencing • circadian rhythm • positive regulation of cellular senescence • spermatogenesis • intrinsic apoptotic signaling pathway in response to DNA damage • cellular response to ionizing radiation • negative regulation of helicase activity • cholesterol homeostasis • response to leptin • cellular response to hypoxia • triglyceride mobilization • negative regulation of prostaglandin biosynthetic process • proteasome-mediated ubiquitin-dependent protein catabolic process • apoptotic process • peptidyl-lysine deacetylation • negative regulation of fat cell differentiation • negative regulation of peptidyl-lysine acetylation • regulation of transcription, DNA-templated • positive regulation of adaptive immune response • stress-induced premature senescence • negative regulation of androgen receptor signaling pathway • negative regulation of transforming growth factor beta receptor signaling pathway • response to oxidative stress • negative regulation of sequence-specific DNA binding transcription factor activity • negative regulation of gene expression • transcription, DNA-templated • negative regulation of cAMP-dependent protein kinase activity • pyrimidine dimer repair by nucleotide-excision repair • response to insulin • histone H3-K9 modification • positive regulation of macroautophagy • positive regulation of cholesterol efflux • protein ubiquitination • negative regulation of cell growth • positive regulation of macrophage apoptotic process • rRNA processing • regulation of brown fat cell differentiation • negative regulation of phosphorylation • viral process • DNA repair • negative regulation of neuron death • positive regulation of histone H3-K9 methylation • negative regulation of histone H3-K14 acetylation • maintenance of chromatin silencing • negative regulation of protein kinase B signaling • cell differentiation • ovulation from ovarian follicle • chromatin silencing • regulation of protein serine/threonine kinase activity • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • protein ADP-ribosylation • leptin-mediated signaling pathway • negative regulation of apoptotic process • negative regulation of transcription from RNA polymerase II promoter • chromatin organization • negative regulation of I-kappaB kinase/NF-kappaB signaling • circadian regulation of gene expression • positive regulation of angiogenesis • protein deacetylation • establishment of chromatin silencing • fatty acid homeostasis • protein destabilization • regulation of mitotic cell cycle • positive regulation of cAMP-dependent protein kinase activity • white fat cell differentiation • positive regulation of insulin receptor signaling pathway • negative regulation of transcription, DNA-templated • negative regulation of NF-kappaB transcription factor activity • peptidyl-lysine acetylation • response to hydrogen peroxide • negative regulation of cellular senescence • intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator • negative regulation of histone H4-K16 acetylation • positive regulation of endothelial cell proliferation • regulation of smooth muscle cell apoptotic process • behavioral response to starvation • cellular glucose homeostasis • cellular response to starvation • cellular response to tumor necrosis factor • positive regulation of DNA repair • regulation of protein import into nucleus, translocation • multicellular organism development • regulation of cell proliferation • positive regulation of cell proliferation • regulation of endodeoxyribonuclease activity • positive regulation of apoptotic process • regulation of cellular response to heat • positive regulation of phosphatidylinositol 3-kinase signaling • negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway • UV-damage excision repair • histone deacetylation • positive regulation of chromatin silencing • positive regulation of transcription from RNA polymerase II promoter • angiogenesis • macrophage cytokine production • regulation of lipid storage • positive regulation of adipose tissue development • macrophage differentiation • transcription from RNA polymerase II promoter • cell aging • response to mycotoxin • positive regulation of heart rate • negative regulation of cardiac muscle cell apoptotic process • positive regulation of neuron projection development • positive regulation of skeletal muscle cell proliferation • response to nutrient levels • negative regulation of tumor necrosis factor production • positive regulation of insulin secretion involved in cellular response to glucose stimulus • negative regulation of DNA binding • negative regulation of neuron apoptotic process • response to ethanol • positive regulation of gluconeogenesis • positive regulation of vasodilation • positive regulation of smooth muscle cell differentiation • negative regulation of growth hormone secretion • negative regulation of cell death • cellular response to hydrogen peroxide • histone H3 deacetylation • cellular response to antibiotic • cellular response to vitamin B3 • cellular response to organic cyclic compound • positive regulation of protein deacetylation • negative regulation of histone H3-K9 trimethylation • negative regulation of protein localization to nucleus • negative regulation of protein acetylation • response to fluoride • negative regulation of reactive oxygen species biosynthetic process • response to kainic acid • response to resveratrol • cellular response to curcumin • cellular response to beta-amyloid • cellular response to rotenone • negative regulation of fibroblast apoptotic process • regulation of energy homeostasis • positive regulation of thyroid-stimulating hormone secretion
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


23411


93759

Ensembl


ENSG00000096717


ENSMUSG00000020063

UniProt


Q96EB6


Q923E4

RefSeq (mRNA)


NM_001142498 NM_001314049 NM_012238


NM_001159589 NM_001159590 NM_019812

RefSeq (protein)


NP_001135970 NP_001300978 NP_036370


NP_062786.1 NP_001153061 NP_062786

Location (UCSC)

Chr 10: 67.88 – 67.92 Mb

Chr 10: 63.32 – 63.38 Mb

PubMed search

4I5I, 4IF6, 4IG9, 4KXQ, 4ZZH, 4ZZI, 4ZZJ, 5BTR

NM_001142498
NM_001314049
NM_012238

NM_001159589
NM_001159590
NM_019812

NP_001135970
NP_001300978
NP_036370

...
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